61186-07-0Relevant academic research and scientific papers
Preparation method of N-methyltyramine hydrochloride
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Paragraph 0039; 0041-0049, (2021/11/26)
The invention discloses a preparation method of N-methyltyramine hydrochloride. The method comprises the following steps: carrying out amination reaction on 4-(2-bromoethyl) phenol and a proper excess amount of monomethylamine according to a molar ratio of 4-(2-bromoethyl) phenol to monomethylamine of 1: (10-30) mol; meanwhile, a solvation effect is exerted, and a large amount of dilution is realized, so that the contact reaction opportunity of a generated product and 4-(2-bromoethyl)phenol which is added later is greatly reduced; and the high product yield can be kept, and meanwhile the low preparation cost is achieved. The invention further provides two simple and convenient recycling methods. Waste discharge can be greatly reduced, economic benefits of the preparation process are improved, and meanwhile a good environment protection effect is achieved.
Process for making galantamine
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Page/Page column 5, (2008/12/04)
A novel process for the preparation of N-methyl-N-(2-[4-hydroxyphenyl]ethyl)-5-hydroxy-4-methoxy benzene carboxamide, which is useful as an intermediate in the synthesis of (?)-galantamine, comprises the reaction of a 5-hydroxy-4-methoxy benzoic acid derivative with N-methyl-N-(2-[4-hydroxyphenyl]ethyl)amine.
