370-98-9

Basic information

• Product Name: 4-(2-METHYLAMINO-ETHYL)-PHENOL
• Synonyms: methyl-4-tyramine;n-methyl-tyramin;p-(2-methylaminoethyl)-pheno;p-(2-methylaminoethyl)phenol;N-METHYL-P-TYRAMINE;4-(2-METHYLAMINO-ETHYL)-PHENOL;4-HYDROXY-N-METHYLPHENETHYLAMINE;N-Methyltyramine hydrochloride
• CAS NO: 370-98-9
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.21
• EINECS: 206-731-3
• Product Categories: pharmacetical
• Mol File: 370-98-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 130～131℃
• Boiling Point: 270.9 °C at 760 mmHg
• Flash Point: 119.7 °C
• Appearance: /
• Density: 1.036 g/cm³
• Vapor Pressure: 0.004mmHg at 25°C
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 9.86±0.15(Predicted)
• CAS DataBase Reference: 4-(2-METHYLAMINO-ETHYL)-PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-METHYLAMINO-ETHYL)-PHENOL(370-98-9)
• EPA Substance Registry System: 4-(2-METHYLAMINO-ETHYL)-PHENOL(370-98-9)

Safety Data

• Hazardous Substances Data: 370-98-9(Hazardous Substances Data)

Usage

General Description

4-(2-Methylamino-ethyl)-phenol is a chemical compound with the molecular formula C9H13NO. It belongs to the class of phenols and is a derivative of phenethylamine. It is commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. 4-(2-METHYLAMINO-ETHYL)-PHENOL has a hydroxyl group (-OH) attached to the benzene ring, as well as a 2-methylamino-ethyl group (-CH2CH2NHCH3) attached in the para position. It is also known by the trade name "Diphenol Methylethylamine." This chemical has various industrial and research applications, particularly in the production of drugs and other organic compounds.

InChI:InChI=1/C9H13NO.ClH/c1-10-7-6-8-2-4-9(11)5-3-8;/h2-5,10-11H,6-7H2,1H3;1H

Upstream product

• 67-56-1 methanol 
• 51-67-2 tyrosamine 
• 14140-15-9 4-(2-bromoethyl)phenol 
• 74-89-5 methylamine 
• 14425-64-0 4-methoxyphenethyl bromide 
• 61186-07-0 N-methyl-N-(2-[4-hydroxyphenyl]ethyl)amine hydrobromide 
• 539-15-1 N,N-dimethyltyramine 
• 64643-79-4 Carbonic acid 4-(2-dimethylamino-ethyl)-phenyl ester vinyl ester 
• 55-81-2 4-Methoxyphenethylamine 
• 871894-82-5 N-(4-methoxyphenethyl)-N-methylacetamide 
• 54815-19-9 N-(4-methoxyphenylethyl)acetamide 
• 25413-27-8 3-(4-methoxy-phenyl)propionamide 
• 60-18-4 L-tyrosine 
• 57933-99-0 Carbonic acid 4-[2-(methyl-vinyloxycarbonyl-amino)-ethyl]-phenyl ester vinyl ester 

Downstream Products

• 24958-44-9 2-bromo-4-methoxy-5-hydroxy-N-[2-(4-hydroxyphenyl)-ethyl]-N-methylbenzamide 
• 112196-70-0 N-tert-butoxycarbonyl-N-methyl-2-(4-hydroxyphenyl)-ethylamine 
• 13062-76-5 N-Methyltyramine hydrochloride 
• 857945-41-6 N-(4-hydroxy-3-nitro-phenethyl)-N-methyl-acetamide 
• 1976-98-3 (4-hydroxyphenethyl)trimethylammonium iodide 
• 859324-01-9 4-(2-methylamino-ethyl)-2-nitro-phenol 

Relevant articles and documents

SIGMA-1 RECEPTOR LIGANDS AND METHODS OF USE

The invention provides compounds of formula I and compositions thereof. The invention further provides methods of using the compounds and compositions. The compounds of the invention can provide high affinity binding to sigma-1 receptors in a mammal. The compounds can exhibit selectivity for the sigma-1 receptor over the sigma-2 receptor. The compounds and compositions of the invention can also be used to treat conditions that involve the sigma-1 receptor, such as addiction, cardiovascular conditions, and cancer, for example, cancer of the breast, lung, prostate, ovarian, colorectal, or the CNS.

Process for making galantamine

A novel process for the preparation of N-methyl-N-(2-[4-hydroxyphenyl]ethyl)-5-hydroxy-4-methoxy benzene carboxamide, which is useful as an intermediate in the synthesis of (?)-galantamine, comprises the reaction of a 5-hydroxy-4-methoxy benzoic acid derivative with N-methyl-N-(2-[4-hydroxyphenyl]ethyl)amine.