612065-40-4Relevant academic research and scientific papers
Four-component reactions for a new diastereoselective synthesis of chiral quaternary centers
Sklute, Genia,Amsallem, Deborah,Shabli, Amal,Varghese, Jos P.,Marek, Ilan
, p. 11776 - 11777 (2003)
The one-pot preparation of chiral homoallylic alcohol and amine derivatives was easily achieved by carbocupration of alkynyl sulfoxides followed by an in situ zinc homologation and reaction with aldehydes or imines. In this process, three new carbon-carbon bonds were created as well as quaternary and tertiary chiral centers with excellent diastereo- and enantioselectivities. Copyright
A shift in retrosynthetic paradigm
Marek, Ilan
scheme or table, p. 7460 - 7468 (2009/09/05)
The current state-of-the-art synthesis for the formation of enantiomerically enriched all-carbon quaternary Stereocenters in acyclic system relies on the formation of a single carbon-carbon bond per chemical step by asymmetric catalysis. These extraordina
New multicomponent approach for the creation of chiral quaternary centers in the carbonyl allylation reactions
Sklute, Genia,Marek, Ilan
, p. 4642 - 4649 (2007/10/03)
The combined regio- and stereo-controlled carbometalation reaction of alkynyl sulfoxide followed by a zinc homologation and finally an allylation reaction led, in a single-pot operation, to chiral homoallylic alcohols in excellent yields and diastereosele
