612069-27-9

Basic information

• Product Name: N',N'-Di(desmethyl) Azithromycin
• Synonyms: N',N'-Di(desmethyl) Azithromycin;3'-N,N-Di(desMethyl) AzithroMycin;(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(3-AMino-3,4,6-trideoxy-β-D-xylo-hexopyranosyl)oxy]-13-[(2,6-dideoxy-3-C-Methyl-3-O-Methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptaMethyl-1-oxa-;3a€-N,N-Di(desmethyl) Azithromycin;3′-(N,N-Didemethyl)azithromycin;Azithromycin EP mpurity E
• CAS NO: 612069-27-9
• Molecular Formula: C36H68N2O12
• Molecular Weight: 720.93132
• Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 612069-27-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 817.289°C at 760 mmHg
• Flash Point: 448.08°C
• Appearance: /
• Density: 1.206g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.542
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 13.28±0.70(Predicted)
• CAS DataBase Reference: N',N'-Di(desmethyl) Azithromycin(CAS DataBase Reference)
• NIST Chemistry Reference: N',N'-Di(desmethyl) Azithromycin(612069-27-9)
• EPA Substance Registry System: N',N'-Di(desmethyl) Azithromycin(612069-27-9)

Safety Data

• Hazardous Substances Data: 612069-27-9(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 612069-27-9 differently. You can refer to the following data:
1. A metabolite of Azithromycin.
2. A metabolite of Azithromycin. Azithromycin Impurity E

InChI:InChI=1/C36H68N2O12/c1-13-25-36(10,44)29(40)22(6)38(11)17-18(2)15-34(8,43)31(50-33-27(39)24(37)14-19(3)46-33)20(4)28(21(5)32(42)48-25)49-26-16-35(9,45-12)30(41)23(7)47-26/h18-31,33,39-41,43-44H,13-17,37H2,1-12H3/t18-,19?,20+,21-,22-,23?,24?,25-,26?,27?,28+,29-,30?,31-,33?,34-,35?,36-/m1/s1

Upstream product

• 83905-01-5 Zithromax(R) 
• 172617-84-4 (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)‐2‐ethyl‐3,4,10‐trihydroxy‐13‐{(2R,4R,5S,6S)‐5‐hydroxy‐4‐methoxy‐4,6‐dimethyl-tetrahydropyran‐2‐yloxy}‐11‐{(2S,3R,4S,6R)‐3‐hydroxy‐6‐methyl‐4‐methylamino-tetrahydropyran‐2‐yloxy}‐3,5,6,8,10,12,14‐heptamethyl‐1‐oxa‐6‐azacyclopentadecan‐15‐one 

Downstream Products

• 612069-25-7 desdimethyl-keto-AZT 

Relevant articles and documents

Macrocyclic lactone impurity synthetic method

The invention relates to a method for preparing an azithromycin impurity I and an azithromycin impurity E. The method comprises the following steps: mixing azithromycin with a solvent, and adding the mixture into a compound which is shown as (I) in the description to perform a demethylation reaction, wherein R1 and R2 are respectively and independently methyl, ethyl, propyl, naphthenic group, a phenyl and p-methylphenyl. According to the method for preparing azithromycin impurity, the reaction is carried out under a mild condition; the method can be used for preparing the azithromycin impurity I and the azithromycin impurity E by controlling the amount of a reagent; the HPLC purity of the azithromycin impurities prepared by the method is 98 percent or more.

Derivatives of azithromycin

The invention relates to derivatives of azithromycin, processes for the manufacture thereof and pharmaceutical compositions thereof preferably together with azithromycin.