612097-74-2

Usage

Structure

Ethyl ester derivative of 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1-piperidinecarboxylic acid

Receptor interaction

Potent and selective antagonist of the adenosine A1 receptor

Therapeutic applications

Potential use in the treatment of various diseases and disorders, including cardiovascular and neurodegenerative conditions

Analgesic and anxiolytic properties

Has shown promise as an analgesic and anxiolytic agent

Research and development

Further studies may lead to the discovery of new pharmaceutical drugs with improved efficacy and safety profiles

InChI:InChI=1/C15H19N3O2/c1-2-20-15(19)18-8-5-11(6-9-18)13-10-17-14-12(13)4-3-7-16-14/h3-4,7,10-11H,2,5-6,8-9H2,1H3,(H,16,17)

Upstream product

• 149692-82-0 3-piperidin-4-yl-1H-pyrrolo[2,3-b]pyridine 
• 541-41-3 chloroformic acid ethyl ester 
• 612097-82-2 ethyl 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-5, 6-dihydropyridine-1(2H)-carboxylate 
• 271-63-6 7-Azaindole 
• 29976-53-2 N-ethoxycarbonyl-4-piperidone 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of piperidinylpyrrolopyridine derivatives as potent and selective H1 antagonists

The synthesis and structure-activity relationships of piperidinylpyrrolopyridines as potent and selective H1 antagonists are discussed. It was found that the nature of the acid chain bonded to piperidine was a key feature for maintaining both the duration of action in vivo and lack of sedative properties.

AZAINDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS

This invention is directed to new potent and selective antagonists of H1 histamine receptors having the general formula (I) to processes for their preparation; to pharmaceutical compositions comprising them; and to their use in therapy.