1-Piperidinecarboxylic acid, 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-, ethyl ester

Base Information

• Chemical Name: 1-Piperidinecarboxylic acid, 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-, ethyl ester
• CAS No.: 612097-74-2
• Molecular Formula: C15H19N3O2
• Molecular Weight: 273.33
• Hs Code.: 2933990090
• Mol file: 612097-74-2.mol

Synonyms:1-Piperidinecarboxylic acid, 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-, ethyl ester

Chemical Property of 1-Piperidinecarboxylic acid, 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-, ethyl ester

Chemical Property:

• Vapor Pressure: 9.69E-09mmHg at 25°C
• Refractive Index: 1.612
• Boiling Point: 462.7°C at 760 mmHg
• Flash Point: 233.6°C
• PSA: 58.22000
• Density: 1.234g/cm³
• LogP: 2.83670
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

Ethyl4-(1H-pyrrolo[2,3-b]pyridin-3-yl)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-, ethyl ester

There total 5 articles about 1-Piperidinecarboxylic acid, 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

ethyl 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-5, 6-dihydropyridine-1(2H)-carboxylate (612097-82-2) → 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-piperidine-1-carboxylic acid ethyl ester (612097-74-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; for 24h; under 1551.49 Torr; Product distribution / selectivity;

Reference yield: 59.0%

3-piperidin-4-yl-1H-pyrrolo[2,3-b]pyridine (149692-82-0) + chloroformic acid ethyl ester (541-41-3) → 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-piperidine-1-carboxylic acid ethyl ester (612097-74-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 6h; Product distribution / selectivity;

Reference yield:

4-pyrrolo[2,3-b]pyridin-3-ylidene-piperidine-1-carboxylic acid ethyl ester → 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-piperidine-1-carboxylic acid ethyl ester (612097-74-2)

Guidance literature:

With hydrogen; platinum(IV) oxide; In methanol; for 1h; under 1551.44 Torr;

DOI:10.1016/j.bmcl.2004.12.008

upstream raw materials:

3-piperidin-4-yl-1H-pyrrolo[2,3-b]pyridine

chloroformic acid ethyl ester

ethyl 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-5, 6-dihydropyridine-1(2H)-carboxylate

7-Azaindole