61219-76-9Relevant articles and documents
Synthesis of deuterated mevalonolactone isotopomers
Dickschat, Jeroen S.,Citron, Christian A.,Brock, Nelson L.,Riclea, Ramona,Kuhz, Henning
experimental part, p. 3339 - 3346 (2011/08/03)
A synthetic route was developed for the preparation of deuterated mevalonolactones. Using low-cost deuterated reagents, this route allows for the independent introduction of deuterium labeling into any carbon position or into any combination of positions. Following this approach, the synthesis of [6,6,6-2H3]mevalonolactone, [4,4,6,6,6-2H 5]mevalonolact-one, [5,5-2H2]mevalonolactone, [5,5,6,6,6-2H5]mevalonolact-one, and [2,2,6,6,6- 2H5]mevalonolactone is described.
Stereochemistry of formation of the β-ring of lycopene: Biosynthesis of (1R,1′R)-β,β-[16,16,16,16′,16′,16′- 2H6]carotene from [16,16,16,16′,16′,16′-2H6] lycopene in flavobacterium R 1560
Mohanty, Sasank Sekhar,Uebelhart, Peter,Eugster, Conrad Hans
, p. 2036 - 2053 (2007/10/03)
Incubation of deuteriated precursors in cultures of Flavobacterium produced specifically deuteriated carotenoids. Analysis of these led to several conclusions: i) Lycopene is a direct precursor of β,β-carotene. ii) Its terminal Me groups retain their inte
Ring D Expansion and Aromatisation in the Biosynthesis of Nic-1, an Antifeedant Steroid from Nicandra physaloides
Gill, Harjit K.,Smith, Roland W.,Whiting, Donald A.
, p. 2989 - 2993 (2007/10/02)
Isotope administration experiments with Nicandra physaloides plants using 2H3>- and 14C3>-mevalonic acid, analysed by 2H NMR and by degradation, respectively, show that the aromatic ring-D of Nic-1 (2) is formed by ring-D expansion in a steroid precursor with oxidative inclusion of the C/D angular methyl.