320749-20-0Relevant academic research and scientific papers
A Modular Synthesis of Some Biologically Relevant Cyclic Peptides through Late-Stage Functionalization
Mukherjee, Jyoti Prasad,Sil, Suman,Pahari, Amit K.,Chattopadhyay, Shital K.
, p. 1181 - 1190 (2016/05/11)
A modular synthesis of some cyclic peptides related to a class of histone deacetylase inhibitors is reported. The synthesis utilizes a late-stage functionalization of a cyclic tetrapeptide scaffold to link the pendant alkyl chain through cross metathesis. It is observed that while the cross-metathesis reaction of a terminal olefin having a β-substituent is marginally successful with the scaffold, the corresponding reaction with an α,β-unsaturated ketone/ester is more promising. The utility of the protocol is demonstrated through the preparation of three cyclic tetrapeptides structurally related to the novel histone deacetylase inhibitors FR-225497 and trapoxin B.
C-20 STEROID COMPOUNDS, COMPOSITIONS AND USES THEREOF TO TREAT TRAUMATIC BRAIN INJURY (TBI), INCLUDING CONCUSSIONS
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Page/Page column 38; 53; 54, (2016/04/09)
The present invention relates to C-20 steroid compounds, compositions and methods of use thereof to treat, minimize and/or prevent traumatic brain injury (TBI), including severe TBI, moderate TBI and mild TBI, including concussions.
C-20 STEROID COMPOUNDS, COMPOSITIONS, AND USES THEREOF TO TREAT TRAUMATIC BRAIN INJURY (TBI), INCLUDING CONCUSSIONS
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Page/Page column 64; 65, (2017/01/09)
The present invention relates to C-20 steroid compounds, compositions and methods of use thereof to treat, minimize and/or prevent traumatic brain injury (TBI), including severe TBI, moderate TBI and mild TBI, including concussions.
SYNTHESIS OF ENT-PROGESTERONE AND INTERMEDIATES THEREOF
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Paragraph 0083; 0176, (2015/07/02)
The present invention relates to the synthesis of ent-progesterone and intermediates thereof.
Practical synthesis of [3-(2H3)methyl]mevalonolactone and incorporation experiment of [3-(2H3)methyl]mevalonolactone and [13C]labeled acetate in the biosynthesis of isoprenoidal diether lipids of halophilic archaea
Yamauchi,Natsubori,Murae
, p. 2513 - 2519 (2007/10/03)
The biosynthesis of the saturated isoprenoid portion of membrane lipids of the halophilic archaea Natrinema pallidum was investigated. At first, a practical method for the synthesis of [3-(2H3)methyl]mevalonate was developed. Then, incorporation experiments of [3-(2H3)methyl]mevalonate into the lipid core indicated that the isoprenoid portion was derived from mevalonate. However, a [2-13C]acetate-incorporation experiment revealed a significant difference in the degree of 13C enrichment between the expected position from the mevalonate pathway, the CH2 groups (and at one terminal CH3 group) and the CH3 groups in the saturated isoprenoid chain. These results suggest that (1) the mevalonate pathway exists and is active, and (2) a part of acetoacetyl-CoA is not derived from an acetate in the biosynthesis of the isoprenoidal lipid-core of the archaebacterium.
