117661-29-7Relevant academic research and scientific papers
A highly stereoselective synthesis of Z-disubstituted olefin by O-assisted Still-Wittig rearrangement
Fujii, Kazushige,Hara, Osamu,Fujita, Yoko,Sakagami, Youji
, p. 389 - 392 (1996)
In the Still-Wittig rearrangement, stannylated methyl (E)-allylic ethers having an aliphatic side chain (1a-c) exhibited the usual similar stereoselectivity, although the poor stereoselectivity was remarkably improved by the assistance of an alkoxy moiety on the alkenyl chain. A stannylated methyl (Z)-allylic ether bearing an alkoxy moiety on the alkenyl chain (1e) also showed a high E selectivity as previously reported.
Regio- And Enantioselective Iridium-Catalyzed Amination of Alkyl-Substituted Allylic Acetates with Secondary Amines
Jung, Woo-Ok,Yoo, Minjin,Migliozzi, Madyson M.,Zbieg, Jason R.,Stivala, Craig E.,Krische, Michael J.
supporting information, p. 441 - 445 (2021/12/27)
Robust air-stable cyclometalated π-allyliridium C,O-benzoates modified by (S)-tol-BINAP catalyze the reaction of secondary aliphatic amines with racemic alkyl-substituted allylic acetates to furnish products of allylic amination with high levels of enantioselectivity. Complete branched regioselectivities were observed despite the formation of more highly substituted C-N bonds.
Visible-Light Photoredox-Catalyzed α-Regioselective Conjugate Addition of Allyl Groups to Activated Alkenes
Gontala, Arjun,Woo, Sang Kook
supporting information, p. 3223 - 3228 (2020/07/06)
The α-regioselective conjugate addition of allyl groups to activated alkenes is a poorly explored area of research. Herein, we report an α-adduct and (E)-isomer selective conjugate addition of allylsilanes to activated alkenes by visible-light photoredox catalysis. The reaction involves allylic radicals that can be generated from allylsilanes through a photoinduced single-electron transfer mechanism. (Figure presented.).
Catalytic Hydroetherification of Unactivated Alkenes Enabled by Proton-Coupled Electron Transfer
Knowles, Robert R.,Metrano, Anthony J.,Tsuchiya, Yuto,Tsui, Elaine
supporting information, p. 11845 - 11849 (2020/05/22)
We report a catalytic, light-driven method for the intramolecular hydroetherification of unactivated alkenols to furnish cyclic ether products. These reactions occur under visible-light irradiation in the presence of an IrIII-based photoredox catalyst, a Br?nsted base catalyst, and a hydrogen-atom transfer (HAT) co-catalyst. Reactive alkoxy radicals are proposed as key intermediates, generated by direct homolytic activation of alcohol O?H bonds through a proton-coupled electron-transfer mechanism. This method exhibits a broad substrate scope and high functional-group tolerance, and it accommodates a diverse range of alkene substitution patterns. Results demonstrating the extension of this catalytic system to carboetherification reactions are also presented.
C-20 STEROID COMPOUNDS, COMPOSITIONS AND USES THEREOF TO TREAT TRAUMATIC BRAIN INJURY (TBI), INCLUDING CONCUSSIONS
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, (2016/04/09)
The present invention relates to C-20 steroid compounds, compositions and methods of use thereof to treat, minimize and/or prevent traumatic brain injury (TBI), including severe TBI, moderate TBI and mild TBI, including concussions.
A Modular Synthesis of Some Biologically Relevant Cyclic Peptides through Late-Stage Functionalization
Mukherjee, Jyoti Prasad,Sil, Suman,Pahari, Amit K.,Chattopadhyay, Shital K.
, p. 1181 - 1190 (2016/05/11)
A modular synthesis of some cyclic peptides related to a class of histone deacetylase inhibitors is reported. The synthesis utilizes a late-stage functionalization of a cyclic tetrapeptide scaffold to link the pendant alkyl chain through cross metathesis. It is observed that while the cross-metathesis reaction of a terminal olefin having a β-substituent is marginally successful with the scaffold, the corresponding reaction with an α,β-unsaturated ketone/ester is more promising. The utility of the protocol is demonstrated through the preparation of three cyclic tetrapeptides structurally related to the novel histone deacetylase inhibitors FR-225497 and trapoxin B.
C-20 STEROID COMPOUNDS, COMPOSITIONS, AND USES THEREOF TO TREAT TRAUMATIC BRAIN INJURY (TBI), INCLUDING CONCUSSIONS
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, (2017/01/09)
The present invention relates to C-20 steroid compounds, compositions and methods of use thereof to treat, minimize and/or prevent traumatic brain injury (TBI), including severe TBI, moderate TBI and mild TBI, including concussions.
SYNTHESIS OF ENT-PROGESTERONE AND INTERMEDIATES THEREOF
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, (2015/07/02)
The present invention relates to the synthesis of ent-progesterone and intermediates thereof.
A stereoselective aldol approach for the total syntheses of two 6-Alkylated 2H-pyran-2-ones
Rajaram, Singanaboina,Ramesh, Dasari,Ramulu, Udugu,Prabhakar, Peddikotla,Venkateswarlu, Yenamandra
, p. 112 - 121 (2014/02/14)
A simple and highly efficient stereoselective total synthesis of the 6-alkylated pyranones (6R)-6-[(1E,4R,6R)-4,6-dihydroxy-10-phenyldec-1-en-1-yl]- 5,6-dihydro-2H-pyran-2-one (1) and (6S)-5,6-dihydro-6-[(2R)-2-hydroxy-6- phenylhexyl]-2H-pyran-2-one (2) w
A convergent and stereoselective total synthesis of phomolides G and H
Subba Reddy,Sivaramakrishna Reddy,Phaneendra Reddy,Yadav
, p. 501 - 504 (2014/03/21)
A stereoselective total synthesis of phomolides G and H, a polyketide natural products is described. The synthesis involves organocatalytic enantioselective asymmetric epoxidation, C1-Wittig olefination, and ring-closing metathesis as key steps. The use of organocatalytic MacMillan asymmetric epoxidation for the construction of two chiral centers of phomolides G and H makes this approach more attractive. Georg Thieme Verlag Stuttgart New York.
