6125-63-9

Basic information

• Product Name: (E)-3-(2-furyl)acrylonitrile
• Synonyms: (E)-3-(2-furyl)acrylonitrile;(E)-3-(2-Furanyl)acrylonitrile;(E)-3-(2-Furanyl)propenenitrile;(E)-3-(2-Furyl)-2-propenenitrile;(αE)-2-Furanacrylonitrile;(αE)-Furan-2-acrylonitrile;(E)-3-(furan-2-yl)prop-2-enenitrile
• CAS NO: 6125-63-9
• Molecular Formula: C₇H₅NO
• Molecular Weight: 119.1207
• Product Categories: Heterocyclic Compounds
• Mol File: 6125-63-9.mol
• Article Data: 26

Chemical Properties

• Melting Point: 34 °C
• Boiling Point: 216.8 °C at 760 mmHg
• Flash Point: 87.2 °C
• Appearance: /
• Density: 1.117 g/cm³
• CAS DataBase Reference: (E)-3-(2-furyl)acrylonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(2-furyl)acrylonitrile(6125-63-9)
• EPA Substance Registry System: (E)-3-(2-furyl)acrylonitrile(6125-63-9)

Safety Data

• Hazardous Substances Data: 6125-63-9(Hazardous Substances Data)

Usage

General Description

(E)-3-(2-furyl)acrylonitrile is a chemical compound with the molecular formula C7H5NO. It is a yellow liquid with a strong, sweet, and nutty odor. (E)-3-(2-furyl)acrylonitrile is used in the production of perfumes, pharmaceuticals, and other organic chemicals. It is also used as a precursor in organic synthesis reactions, particularly in the formation of heterocyclic compounds. (E)-3-(2-furyl)acrylonitrile is considered to be a hazardous chemical, and exposure to high concentrations can cause irritation to the skin, eyes, and respiratory system. It is important to handle and store this compound with care and in accordance with safety regulations.

Upstream product

• 98-01-1 furfural 
• 2181-42-2 trimethylsulphonium iodide 
• 75-05-8 acetonitrile 
• 590-17-0 cyanomethyl bromide 
• 39511-08-5 (E)-3-(2-furanyl)-2-propenal 
• 98-00-0 (2-furyl)methyl alcohol 
• 4336-70-3 (cyanomethyl)triphenylphosphonium chloride 
• 773837-37-9 sodium cyanide 
• 100074-10-0 2,2-dibromovinyl-2-furan 
• 16640-68-9 cyanomethylene triphenylphosphorane 
• 793706-87-3 (1,1-dimethylethoxy)diphenylsilylacetonitrile 
• 122-52-1 triethyl phosphite 
• 527-69-5 2-furancarbonyl chloride 
• 107-13-1 acrylonitrile 

Downstream Products

• 135547-96-5 3-(3-Benzoyl-thioureido)-4-furan-2-ylmethyl-1H-pyrrole-2-carboxylic acid methyl ester 
• 135547-97-6 3-(3-Benzoyl-2-methyl-isothioureido)-4-furan-2-ylmethyl-1H-pyrrole-2-carboxylic acid methyl ester 
• 604800-01-3 1-[2-(2-furanyl)vinyl]cyclopropylamine 
• 18873-35-3 (Z)-β-(5-Nitro-fur-2-yl)-acrylonitril 
• 18873-36-4 (E)-β-(5-Nitro-fur-2-yl)-acrylonitril 
• 21446-61-7 3-(furan-2-yl)propanenitrile 
• 539-47-9 3-(fur-2-yl)crotonic acid 

Relevant articles and documents

Preparation method of nitrile compound

The present invention belongs to the field of organic synthesis technology, specifically relates to a method for preparing a nitrile compound, aldehyde oxime derivatives as raw materials, adding DPPA and DBU, reacting in an organic solvent, one step to pr

Selective and facile synthesis of α,β-unsaturated nitriles and amides with N-hydroxyphthalimide as the nitrogen source

The direct conversion of α,β-unsaturated aldehydes to corresponding nitriles promoted by Pd(OAc)2 and phthalic acid which was hydrolyzed from N-hydroxyphthalimide (NHPI) has been disclosed. Additionally, it was found that when water was used as the solvent, α,β-unsaturated amides was obtained as the main products in good to excellent yields. It was first reported that NHPI was utilized as the nitrogen source to synthesize α,β-unsaturated nitriles and amides from aldehydes. Control experiment demonstrated that aldehydes undergo a process of oximation and dehydration to form nitriles and amides.

Development and Utilization of a Palladium-Catalyzed Dehydration of Primary Amides to Form Nitriles

A palladium(II) catalyst, in the presence of Selectfluor, enables the efficient and chemoselective transformation of primary amides into nitriles. The amides can be attached to aromatic rings, heteroaromatic rings, or aliphatic side chains, and the reactions tolerate steric bulk and electronic modification. Dehydration of a peptaibol containing three glutamine groups afforded structure-activity relationships for each glutamine residue. Thus, this dehydration can act similarly to an alanine scan for glutamines via synthetic mutation.