2343-25-1

Basic information

• Product Name: 2-AMINO-5-FLUOROACETOPHENONE
• Synonyms: 1-(2-amino-5-fluorophenyl)ethan-1-one;1-(2-Amino-5-fluorophenyl);2-AMINO-5-FLUOROACETOPHENONE;1-(2-AMino-5-fluorophenyl)ethanone
• CAS NO: 2343-25-1
• Molecular Formula: C₈H₈FNO
• Molecular Weight: 153.155
• Mol File: 2343-25-1.mol
• Article Data: 13

Chemical Properties

• Melting Point: 64-65 °C
• Boiling Point: 264.232°C at 760 mmHg
• Flash Point: 113.604°C
• Appearance: /
• Density: 1.202g/cm³
• Vapor Pressure: 0.01mmHg at 25°C
• Refractive Index: 1.548
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.37±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-5-FLUOROACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-FLUOROACETOPHENONE(2343-25-1)
• EPA Substance Registry System: 2-AMINO-5-FLUOROACETOPHENONE(2343-25-1)

Safety Data

• Hazardous Substances Data: 2343-25-1(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 2343-25-1 differently. You can refer to the following data:
1. 1-(2-Amino-5-fluorophenyl)ethanone is a useful research chemical.
2. 2-Amino-5-fluoroacetophenone can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

Synthesis

600 g of 2-ethynyl-4-fluoroaniline and 4 L of water were added to the reaction flask, and then 476 g of hydrochloric acid (concentration: 35%) was added, and thereaction was carried out at 50 °C for 36 hours.After the reaction, the temperature is lowered to 20-25 °C, the reaction solution is adjusted to pH 8-9 with 50% sodium hydroxide solution, thetemperature is controlled to not exceed 30 °C during pH adjustment, and the filter cake is washed with 1 L of water and decompressed at 50 °C. After drying for 12 h, 622 g of pale yellow solid was obtained, yield91.4%.HPLC purity was 99.2%.

InChI:InChI=1/C8H8FNO/c1-5(11)7-4-6(9)2-3-8(7)10/h2-4H,10H2,1H3

Upstream product

• 61272-77-3 2-cyano-4-fluoroaniline 
• 887903-03-9 4-fluoro-2-ethynylaniline 
• 676-58-4 methylmagnesium chloride 
• 75-05-8 acetonitrile 
• 371-40-4 4-fluoroaniline 
• 446-08-2 2-amino-5-fluorobenzoic acid 
• 917-54-4 methyllithium 
• 75-16-1 methylmagnesium bromide 
• 351-83-7 4'-fluoroacetanilide 

Downstream Products

• 1417901-30-4 1-((5-fluoro-2-(phenylamino))phenyl)ethanone 
• 1595283-06-9 4-fluoro-2-(α-styryl)aniline 
• 5273-41-6 4-fluoro-2-(prop-1-en-2-yl)aniline 
• 914225-70-0 1-(5-fluoro-2-iodophenyl)ethan-1-one 

Relevant articles and documents

Catalytic Asymmetric Addition of Diorganozinc Reagents to Pyrazole-4,5-Diones and Indoline-2,3-Diones

The catalytic enantioselective diorganozinc additions to cyclic diketones including pyrazolin-4,5-diones and isatins have been developed. In the presence of morpholine-containing chiral amino alcohol ligand, the corresponding chiral cyclic tertiary alcohols were produced in good to excellent yields (up to 97 %) and enantioselectivities (up to 95 % ee). The notable feature of this protocol includes its mild reaction conditions, Lewis acid additives free and broad functional group tolerance.

Preparation method of lorlatinib intermediate compound

The invention relates to a preparation method of a lorlatinib intermediate compound. 4-fluoroacetanilide is taken as a raw material and carry out visible light Fries rearrangement in the presence of avisible light catalyst and visible light to obtain an i

Water-Soluble Hypervalent Iodine(III) Having an I-N Bond. A Reagent for the Synthesis of Indoles

A readily accessible and bench-stable water-soluble hypervalent iodine(III) reagent (phenyliodonio)sulfamate (PISA) with an I-N bond was synthesized, and its structure was characterized by X-ray crystallography. With PISA, various indoles were synthesized via C-H amination of 2-alkenylanilines involving an aryl migration/intramolecular cyclization cascade with excellent regioselectivity in aqueous CH3CN. Notably, using this new method as the key step, not only two drug molecules, indometacin and zidometacin, but also another bioactive molecule, pravadoline, were synthesized.