613-39-8

Basic information

• Product Name: 1,4-DIPHENYLPIPERAZINE
• Synonyms: 1,4-DIPHENYLPIPERAZINE
• CAS NO: 613-39-8
• Molecular Formula: C₁₆H₁₈N₂
• Molecular Weight: 238.33
• EINECS: 210-340-3
• Mol File: 613-39-8.mol
• Article Data: 56

Chemical Properties

• Melting Point: 165°C
• Boiling Point: 370.93°C (rough estimate)
• Flash Point: 176°C
• Appearance: /
• Density: 1.0704 (rough estimate)
• Vapor Pressure: 2.7E-06mmHg at 25°C
• Refractive Index: 1.5635 (estimate)
• CAS DataBase Reference: 1,4-DIPHENYLPIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-DIPHENYLPIPERAZINE(613-39-8)
• EPA Substance Registry System: 1,4-DIPHENYLPIPERAZINE(613-39-8)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 613-39-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 14, p. 535, 1977 DOI: 10.1002/jhet.5570140340The Journal of Organic Chemistry, 52, p. 1673, 1987 DOI: 10.1021/jo00385a006Tetrahedron Letters, 27, p. 377, 1986 DOI: 10.1016/S0040-4039(00)84023-X

InChI:InChI=1/C16H18N2/c1-3-7-15(8-4-1)17-11-13-18(14-12-17)16-9-5-2-6-10-16/h1-10H,11-14H2

Upstream product

• 107-21-1 ethylene glycol 
• 150-61-8 N,N'-diphenylethylenediamine 
• 7025-95-8 N,N'-dimethyl-N,N'-diphenylethylenediamine 
• 106-93-4 ethylene dibromide 
• 7030-59-3 N,N'-diethyl-N,N'-diphenyl-ethylenediamine 
• 62-53-3 aniline 
• 64-17-5 ethanol 
• 127-09-3 sodium acetate 
• 100-61-8 N-methylaniline 
• 107-07-3 2-chloro-ethanol 
• 553-27-5 aniline mustard 
• 110-15-6 succinic acid 
• 696-18-4 1-phenylaziridine 
• 124-38-9 carbon dioxide 

Downstream Products

• 59281-86-6 N-(2-anilino-ethyl)-acetanilide 
• 728938-28-1 N,N'-dinitro-N,N'-dipicryl-ethylenediamine 
• 1426255-14-2 5,5'-((piperazine-1,4-diylbis(1,4-phenylene))bis(diazene-1,2-diyl))bis(2-acetamidobenzenesulfonic acid) 
• 65018-25-9 1,4-bis-(4-bromo-phenyl)-piperazine 
• 1422043-19-3 C₂₆H₃₄N₂Si₂ 
• 1422043-08-0 C₂₀H₁₈N₂ 
• 728-24-5 1,3-diphenyl-2-imidazolidone 
• 858850-94-9 1,4-diphenyl-piperazine-2,3-dione 
• 4963-30-8 di-(4-nitrosophenyl)-N,N-piperazine 
• 187800-49-3 (N,N'-diphenylpiperazine)(1,3-η(3)-propenyl)palladiumtrifluoromethanesulfonate 
• 10159-39-4 4,4’-(1,4-piperazinediyl)bisbenzaldehyde 
• 123183-90-4 4-Phenyl-1-(p-nitroazobenzenyl)piperazine 

Relevant articles and documents

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Functionalization of superparamagnetic Fe3O4@SiO2 nanoparticles with a Cu(II) binuclear Schiff base complex as an efficient and reusable nanomagnetic catalyst for N-arylation of α-amino acids and nitrogen-containing heterocycles with aryl halides

Fe3O4@SiO2 nanoparticles was functionalized with a binuclear Schiff base Cu(II)-complex (Fe3O4@SiO2/Schiff base-Cu(II) NPs) and used as an effective magnetic hetereogeneous nanocatalyst for the N-arylation of α-amino acids and nitrogen-containig heterocycles. The catalyst, Fe3O4@SiO2/Schiff base-Cu(II) NPs, was characterized by Fourier transform infrared (FTIR) and ultraviolet-visible (UV-vis) analyses step by step. Size, morphology, and size distribution of the nanocatalyst were studied by transmission electron microscopy (TEM), scanning electron microscopy (SEM), and dynamic light scatterings (DLS) analyses, respectively. The structure of Fe3O4 nanoparticles was checked by X-ray diffraction (XRD) technique. Furthermore, the magnetic properties of the nanocatalyst were investigated by vibrating sample magnetometer (VSM) analysis. Loading content as well as leaching amounts of copper supported by the catalyst was measured by inductive coupled plasma (ICP) analysis. Also, thermal studies of the nanocatalyst was studied by thermal gravimetric analysis (TGA) instrument. X-ray photoelectron spectroscopy (XPS) analysis of the catalyst revealed that the copper sites are in +2 oxidation state. The Fe3O4@SiO2/Schiff base-Cu(II) complex was found to be an effective catalyst for C–N cross-coupling reactions, which high to excellent yields were achieved for α-amino acids as well as N-hetereocyclic compounds. Easy recoverability of the catalyst by an external magnet, reusability up to eight runs without significant loss of activity, and its well stability during the reaction are among the other highlights of this catalyst.

Photo-induced dealdehyding method

The invention provides a photo-induced dealdehyding method, and belongs to the technical field of organic synthesis. The photo-induced dealdehyding method comprises the following steps that a mixtureof a compound shown in the formula I and a solvent are reacted under an inert gas atmosphere and visible light irradiation, a dealdehyding product is obtained, and no photocatalyst is used in the whole process; wherein the structural formula of the formula I shown in the specification, R is a functional group and is selected from hydrogen, methyl, methoxyl, cyano, chlorine, bromine or fluorine. According to the photo-induced dealdehyding method, in the inert gas atmosphere, the compound shown in the formula (I) can be excited to generate carbon-oxygen bond homogeneous cracking through visiblelight irradiation, then free radical migration and double bond displacement are conducted, finally carbon monoxide is removed, aldehyde group removal is completed, no photocatalyst is needed in the whole process, operation is easy and convenient, and conditions are mild.

Ligand complex of copper (II) supported on superparamagnetic Fe3O4?SiO2 nanoparticles: an efficient and magnetically separable catalyst for N-arylation of nitrogen-containing heterocycles with aryl halides

In this study, we introduce the ligand complex of copper (II) supported on superparamagnetic Fe3O4?SiO2 nanoparticles as a highly intriguing magnetic catalyst in N-arylation of nitrogen heterocycles with aryl halides. The present methodology offers several advantages such as; low catalyst loading, the use of magnetically recoverable and reusable catalyst, high to excellent yields without using any external ligands or additives, short reaction times and simplicity of operation. Also, the magnetic catalyst could be easily separated from the final product by an external magnet and reused up to seven times without any significant loss of activity. Therefore, this separation strategy with negligible leaching makes Fe3O4?SiO2/ligand/Cu(II) an economical catalyst to perform this transformation.