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Basic information

• Product Name: 1,3-diphenylimidazolidin-2-one
• Synonyms: 2-Imidazolidinone, 1,3-diphenyl-; Diphenylimidazolidinone
• CAS NO: 728-24-5
• Molecular Formula: C₁₅H₁₄N₂O
• Molecular Weight: 238.2845
• Mol File: 728-24-5.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 368.2°C at 760 mmHg
• Flash Point: 159.4°C
• Density: 1.217g/cm³
• Vapor Pressure: 1.3E-05mmHg at 25°C
• Refractive Index: 1.634
• CAS DataBase Reference: 1,3-diphenylimidazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-diphenylimidazolidin-2-one(728-24-5)
• EPA Substance Registry System: 1,3-diphenylimidazolidin-2-one(728-24-5)

Safety Data

• Hazardous Substances Data: 728-24-5(Hazardous Substances Data)

Upstream product

• 77-25-8 diethyl diethylmalonate 
• 150-61-8 N,N'-diphenylethylenediamine 
• 75-44-5 phosgene 
• 88734-24-1 2,2'-Diselenobis(1,3-diphenyl-2-imidazolinium)-bis(trifluormethansulfonat) 
• 2179-89-7 bis(1,3-diphenyl-2-imidazolidinylidene) 
• 124-38-9 carbon dioxide 
• 106-93-4 ethylene dibromide 
• 62-53-3 aniline 
• 613-39-8 1,4-diphenyl-piperazine 
• 120-93-4 imidazolidone 
• 591-50-4 iodobenzene 
• 108-86-1 bromobenzene 
• 696-18-4 1-phenylaziridine 
• 103-71-9 phenyl isocyanate 

Downstream Products

• 2513-64-6 1,3-diphenylimidazolidine 
• 7025-95-8 N,N'-dimethyl-N,N'-diphenylethylenediamine 

Relevant articles and documents

Synthetic method of N - aryl substituted lactam compound

The invention discloses a method. NSynthesis method of - aryl substituted lactam compound, and synthesis method thereof is promoted by tertiary butyl hydroperoxide and-tert-butyl hydroperoxideNMulti-step series reaction synthesis - aryl substituted saturated cyclic amine compoundN- Aryl substituted lactam compounds are simple and convenient to operate. The method has the advantages of no transition metal catalysis, wide substrate application range and the like, and is suitable for industrial production.

Complementation of biotransformations with chemical C-H oxidation: Copper-catalyzed oxidation of tertiary amines in complex pharmaceuticals

The isolation, quantitation, and characterization of drug metabolites in biological fluids remain challenging. Rapid access to oxidized drugs could facilitate metabolite identification and enable early pharmacology and toxicity studies. Herein, we compared biotransformations to classical and new chemical C-H oxidation methods using oxcarbazepine, naproxen, and an early compound hit (phthalazine 1). These studies illustrated the low preparative efficacy of biotransformations and the inability of chemical methods to oxidize complex pharmaceuticals. We also disclose an aerobic catalytic protocole (CuI/air) to oxidize tertiary amines and benzylic CH's in drugs. The reaction tolerates a broad range of functionalities and displays a high level of chemoselectivity, which is not generally explained by the strength of the C-H bonds but by the individual structural chemotype. This study represents a first step toward establishing a chemical toolkit (chemotransformations) that can selectively oxidize C-H bonds in complex pharmaceuticals and rapidly deliver drug metabolites.

Mild, convenient and versatile Cu-mediated synthesis of N-aryl-2-imidazolidinones

A mild, general, convenient and practical methodology for the selective copper-mediated mono N-arylation of unprotected 2-imidazolidinone was developed. Strong electron-donating groups and free hydroxy and amino groups on the aryl iodide substrates were well tolerated. The use of n-butanol as the solvent for the copper-catalysed mono-arylation of 2-imidazolidinone is unprecedented.