61310-35-8

Basic information

• Product Name: 4-Pyrimidinamine, 6-methyl-2-(4-pyridinyl)-
• Synonyms: 6-methyl-2-pyridin-4-yl-pyrimidin-4-ylamine
• CAS NO: 61310-35-8
• Molecular Formula: C10H10N4
• Molecular Weight: 186.216
• Mol File: 61310-35-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 192-194 °C(Solv: isopropanol (67-63-0))
• Boiling Point: 288.4±32.0 °C(Predicted)
• Density: 1.217±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-Pyrimidinamine, 6-methyl-2-(4-pyridinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyrimidinamine, 6-methyl-2-(4-pyridinyl)-(61310-35-8)
• EPA Substance Registry System: 4-Pyrimidinamine, 6-methyl-2-(4-pyridinyl)-(61310-35-8)

Safety Data

• Hazardous Substances Data: 61310-35-8(Hazardous Substances Data)

Upstream product

• 61310-34-7 4-hydrazino-6-methyl-2-(4-pyridinyl)pyrimidine 
• 100-48-1 pyridine-4-carbonitrile 
• 75-05-8 acetonitrile 
• 6345-27-3 4-amidinopyridine hydrochloride 
• 61310-33-6 4-Chloro-6-methyl-2-(4-pyridinyl)pyrimidine 
• 59341-68-3 6-methyl-2-(pyridin-4-yl)pyrimidin-4(3H)-one 

Relevant articles and documents

3,5-Dichloro-4-pyridinecarbonitrile: A multisite substrate for carbon nucleophiles

The reactivity of 3,5-dichloro-4-pyridinecarbonitrile (1) towards lithium or magnesium organometallic reagent is described. Conditions for substitution of cyano with alkyl or phenyl group, alkylation at the position 2 with removal of the 5-positioned chlorine, and formation of methyl or phenyl dichloropyridyl imines are reported. The obtained 4-alkyl-3,5-dichloropyridines can undergo a further alkylation at the position 2. The 3,5-dichloro-4-pyridyl residue is shown to be a good leaving group in form of anion yielding 3,5-dichloropyridine either from 1 or 3,5-dichloro-4-pyridinecarboxaldehyde.

N-[2-(pyridinyl)-4-pyrimidinyl]ureas

Compounds useful as anti-allergic agents are N-R3 -N-R4 -N'-R-N'-(2-Q-5-R1 -6-R2 -4-pyrimidinyl)ureas (I), where Q is 4- or 3- or 2-pyridinyl or 4- or 3- or 2-pyridinyl having one or two lower-alkyl substituents or N-oxide thereof, R is hydrogen or lower-alkyl, R1 is hydrogen, lower-alkyl or cyano, R2 is hydrogen or lower-alkyl, R3 is hydrogen, lower-alkyl or lower-hydroxyalkyl, R4 is hydrogen, lower-alkyl, lower-hydroxyalkyl, lower-alkenyl or lower-cycloalkyl. Said ureas are prepared by reacting 2-Q-4-RNH-5-R1 -6-R2 -pyrimidine (II) with a carbamylating agent selected from an R4 '-isocyanate of the formula R4 'N=C=O to produce N-R4 '-N'-R-N'-(2-Q-5-R1 -6-R2 -4-pyrimidinyl)urea (IA), an N-R3 '-N-R4 '-carbamyl halide of the formula R3 'R4 'NC(=O)-halide to produce N-R3 '-N-R4 'N'-R-N'-(2-Q-5-R1 -6-R2 -4-pyrimidinyl)urea (IB) or 1,1'-carbonyldiimidazole to produce N-(2-Q-5-R1 -6-R2 -4-pyrimidinyl)-N-R-imidazole-1-carboxamide and then reacting said 1-carboxamide with R3 R4 NH to produce I.

5,8-Dihydro-5-oxo-2-(4-or 3-pyridinyl)pyrido[2,3-d]pyrimidine-6-carboxylic acids and esters

Antibacterial 5,8-dihydro-8-(lower-alkyl)-5-oxo-2-Q-4-R2 -6-Z-pyrido[2,3-d]pyrimidine (I) where Z is carboxy or lower-carbalkoxy, R2 is hydrogen or lower-alkyl and Q is 4(or 3)-pyridinyl or 4(or 3)-pyridinyl having one or two lower-alkyl substituents is prepared by heating di-(lower-alkyl) N-(2-Q-6-R2 -4-pyrimidinyl)aminomethylenemalonate (III) to produce 5,8-dihydro-5-oxo-2-Q-4-R2 -6-Z-pyrido[2,3-d]pyrimidine (II) which is tautomeric with 5-hydroxy-2-Q-4-R2 -6-Z-pyrido[2,3-d]pyrimidine (IIA) where Q and R2 are the same as in I above and Z is lower-carbalkoxy, reacting II(or IIA) with a lower-alkylating agent to produce I where Z is lower-carbalkoxy and hydrolyzing this ester (I) to produce I where Z is carboxy. Alternatively, the acid (II or IIA where Z is COOH) can be alkylated after first hydrolyzing the ester (II or IIA where Z is lower-carbalkoxy). The preparations of the intermediate III and intermediates used in its preparation are given.