61323-28-2

Upstream product

• 936-61-8 Thiobenzoic acid O-ethyl ester 
• 2999-46-4 Ethyl isocyanoacetate 
• 161198-54-5 methyl N-(ethoxycarbonylmethyl)thioformimidate 
• 3154-51-6 ethyl N-formylglycinate 
• 773837-37-9 sodium cyanide 
• 2168-78-7 methyl dithiobenzoate 
• 98-91-9 thiobenzoic acid 
• 61830-23-7 ethyl 5‐bromo‐1,3‐thiazole‐4‐carboxylate 
• 98-80-6 phenylboronic acid 
• 82954-40-3 N-thioformyl glycine ethyl ester 

Downstream Products

• 838893-03-1 (5-phenylthiazole-4-yl)methanol 
• 127917-64-0 t-butyl [2-(5-phenyl-4-thiazolecarboxamido)ethyl]carbamate 
• 1047671-69-1 1-methyl-4-{[(5-phenyl-1,3-thiazol-4-yl)carbamoyl]oxy}-1-azoniabicyclo[2.2.2]octane iodide 
• 1047671-76-0 (3R)-1-methyl-3-{[(5-phenyl-1,3-thiazol-4-yl)carbamoyl]oxy}-1-azoniabicyclo[2.2.2]octane iodide 
• 13743-14-1 5-phenyl-1,3-thiazole-4-carboxylic acid 
• 1047672-25-2 1-azabicyclo[2.2.2]oct-4-yl (5-phenyl-1,3-thiazol-4-yl)carbamate 
• 1047672-88-7 (3R)-1-azabicyclo[2.2.2]oct-3-yl (5-phenyl-1,3-thiazol-4-yl)carbamate hydrochloride 

Relevant academic research and scientific papers

IAP ANTAGONISTS AND THEIR THERAPEUTIC APPLICATIONS

The present invention relates to Formula I. compounds including their isomers, tautomeric forms and rotamers, salts together with their manufacturing process and their pharmacological use alone or in combination with other active ingredients for the treatment of cell and tissue malignances caused diseases, including uncontrolled cell or tissue growth, proliferation and cancer.

One-pot four-component synthesis of polysubstituted thiazoles via cascade Ugi/Wittig cyclization starting from odorless Isocyano(triphenylphosphoranylidene)-acetates

A new one-pot four-component preparation of polysubstituted thiazoles by a cascade Ugi/Wittig cyclization has been developed. The four-component reactions of the odorless isocyano(triphenylphosphoranylidene)acetates 1, aldehydes 2, amines 3 and thiocarboxylic acids 4 produced 2,4,5-trisubstituted thiazoles 5 in moderate to good yields in the presence of triethylamine. The two-component reactions between isocyano(triphenylphosphoranylidene)acetates 1 and thiocarboxylic acids 4 in the presence of triethylamine provided the corresponding 4,5-disubstituted thiazoles 6 in good yields as well.

Novel quinuclidinyl heteroarylcarbamate derivatives as muscarinic receptor antagonists

Herein, we describe the synthesis and pharmacological profiles of novel quinuclidinyl heteroarylcarbamate derivatives. Among them, the quinuclidin-4-yl thiazolylcarbamate derivative ASP9133 was identified as a promising long-acting muscarinic antagonist (LAMA) showing more selective inhibition of bronchoconstriction against salivation and more rapid onset of action in a rat model than tiotropium bromide.

An easy access to 4,5-disubstituted thiazoles via base-induced click reaction of active methylene isocyanides with methyl dithiocarboxylates

An efficient synthesis of 4,5-disubstituted thiazoles via base-induced cyclization of active methylene isocyanides such as tosylmethyl isocyanide, ethyl isocyanoacetate, and arylmethyl isocyanides with methyl arene- and hetarenecarbodithioates is reported

ARYL GPR120 RECEPTOR AGONISTS AND USES THEREOF

Aryl GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.

INDANE DERIVATES AS MUSCARINIC RECEPTOR AGONISTS

The present invention relates to compounds of Formula I: I which are agonists of the M-1 muscarinic receptor.

Synthesis of oxazoles and thiazoles using thioimidates

Several oxazoles and thiazoles were synthesized easily by the reaction of N-(methylthioalkylidene)glycine ethyl ester with diethyl oxalate, acid halides, and thionesters in the presence of base.