6134-55-0

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
1-bromotetralin is utilized as a starting material in the synthesis of various pharmaceuticals and agrochemicals. Its unique chemical structure allows for the development of new compounds with potential therapeutic and pesticidal properties.
Used in Fragrance and Flavoring Industries:
1-bromotetralin is employed as a key component in the manufacturing of fragrances and flavoring compounds. Its distinct sweet, flowery scent makes it a valuable ingredient in creating a wide range of scents and tastes for various applications.

InChI:InChI=1/C10H11Br/c11-10-7-3-5-8-4-1-2-6-9(8)10/h3,5,7H,1-2,4,6H2

Upstream product

• 119-64-2 tetralin 
• 115227-60-6 Cyclodeca-1,5-diyn-3-ene 
• 2217-41-6 1-amino-5,6,7,8-tetrahydronaphthalene 
• 7789-45-9 copper(II)bromide 
• 68449-30-9 5-bromo-1-tetralone 
• 86-57-7 1-Nitronaphthalene 
• 21336-06-1 1,2-diethynylcyclohex-1-ene 
• 108869-56-3 Cyclodeca-1,3-dien-5-yn-1-yl trifluoromethanesulphonate 
• 166111-53-1 bicyclo[4.4.0]-5-bromo-5⁽⁶⁾-decen-1-ol 

Downstream Products

• 116-69-8 3-bromophthalic acid 
• 113222-47-2 (2-bromo-6-carboxy-phenyl)-glyoxylic acid 
• 113187-11-4 (3-bromo-2-carboxy-phenyl)-glyoxylic acid 
• 1394373-00-2 ethyl 5-(4-chlorophenyl)-4-methyl-3-(4-sulfamoyl-5,6,7,8-tetrahydronaphthalen-1-yl)thiophene-2-carboxylate 
• 1279015-46-1 4-[5,6,7,8-tetrahydronaphthalen-1-yl]phenol 
• 17104-67-5 6-cyano-1,2,3,4-tetrahydronaphthalene 
• 29809-13-0 5,6,7,8-tetrahydronaphthalene-1-carbonitrile 
• 4242-18-6 5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid 
• 1131-63-1 1,2,3,4-tetrahydro-2-naphthoic acid 
• 54538-02-2 5-(2-Aminobenzyl)-tetralin 
• 677325-82-5 4-methyl-5,6,7,8-tetrahydro-[1]naphthylamine 
• 4242-05-1 1-Hydroxy-4-methyl-5,6,7,8-tetrahydro-naphthalin 
• 104778-46-3 5-fluoro-3-(5,6,7,8-tetrahydro-1-naphthalenyl)-1(3H)-isobenzofuranone 
• 54537-97-2 5-(2-Aminobenzoyl)-1,2,3,4-tetrahydronaphthalin 

Relevant academic research and scientific papers

Nucleophilic addition to a p-benzyne derived from an enediyne: A new mechanism for halide incorporation into biomolecules

Biosynthesis of haloaromatics ordinarily occurs by electrophilic attack of an activated halogen species on an electron-rich aromatic ring. We now present the discovery of a new reaction whereby a nucleophilic halide anion can be attached even to an aromatic ring without activating substituents. We show that the enediyne cyclodeca-1,5-diyn-3-ene, in the presence of lithium halide and a weak acid, is converted to 1-halotetrahydronaphthalene. The kinetics are consistent with rate-limiting cyclization to a p-benzyne biradical that rapidly adds halide and is then protonated. This reaction has interesting mechanistic features and important implications for incorporation of halide into biomolecules.

13C scrambling of [5-13C]5-cyclodecynone

Scrambling of [5-13C]5-cyclodecynone occurs as a result of acidic conditions that preclude its rapid consumption. (C) 2000 Elsevier Science Ltd.

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with a defect in glyoxylate metabolism, for example a disease or disorder associated with the enzyme glycolate oxidase (GO) or alterations in oxalate metabolism. Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

Triptycenyl Sulfide: A Practical and Active Catalyst for Electrophilic Aromatic Halogenation Using N-Halosuccinimides

A Lewis base catalyst Trip-SMe (Trip = triptycenyl) for electrophilic aromatic halogenation using N-halosuccinimides (NXS) is introduced. In the presence of an appropriate activator (as a noncoordinating-anion source), a series of unactivated aromatic compounds were halogenated at ambient temperature using NXS. This catalytic system was applicable to transformations that are currently unachievable except for the use of Br2 or Cl2: e.g., multihalogenation of naphthalene, regioselective bromination of BINOL, etc. Controlled experiments revealed that the triptycenyl substituent exerts a crucial role for the catalytic activity, and kinetic experiments implied the occurrence of a sulfonium salt [Trip-S(Me)Br][SbF6] as an active species. Compared to simple dialkyl sulfides, Trip-SMe exhibited a significant charge-separated ion pair character within the halonium complex whose structural information was obtained by the single-crystal X-ray analysis. A preliminary computational study disclosed that the πsystem of the triptycenyl functionality is a key motif to consolidate the enhancement of electrophilicity.

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme glycolate oxidase (GO). Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

New organic compounds and organic light emitting device using the same

The present invention relates to a polycyclic aromatic hydrocarbon compound in which a substituted or unsubstituted C2-30 cycloalkane, or a substituted or unsubstituted C5-50 polycycloalkane is fused to a substituent of said polycyclic aromatic hydrocarbon as represented by formula (3). Furthermore, the present invention relates to an organic light emitting device comprising a first electrode, at least one organic layer and a second electrode, laminated successively, in which at least one organic layer comprises said polycyclic aromatic hydrocarbon compound.

ORGANIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE USING THE SAME

The present invention provides an organic light emitting device comprising a first electrode, at least one organic layer and a second electrode, laminated successively, in which at least one layer of the organic layer has a polycyclic aromatic hydrocarbon as a core and comprises at least one of a derivative in which a substituted or unsubstituted C2-30 cycloalkane, or a substituted or unsubstituted C5-50 polycycloalkane is directly fused to the core or fused to a substituent of the core: and a new organic compound usable in the organic light emitting device. Furthermore, the present invention provides a charge carrier extracting, injecting or transporting material which has a polycyclic aromatic hydrocarbon as a core and comprises a derivative in which a substituted or unsubstituted C2-30 cycloalkane, or a substituted or unsubstituted C5-50 polycycloalkane is directly fused to the core or fused to a substituent of the core.

ORGANIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE USING THE SAME

The present invention provides an organic light emitting device comprising a first electrode, at least one organic layer and a second electrode, laminated successively, in which at least one layer of the organic layer has a polycyclic aromatic hydrocarbon as a core and comprises at least one of a derivative in which a substituted or unsubstituted C2-30 cycloalkane, or a substituted or unsubstituted C5-50 polycycloalkane is directly fused to the core or fused to a substituent of the core; and a new organic compound usable in the organic light emitting device. Furthermore, the present invention provides a charge carrier extracting, injecting or transporting material which has a polycyclic aromatic hydrocarbon as a core and comprises a derivative in which a substituted or unsubstituted C2-30 cycloalkane, or a substituted or unsubstituted C5-50 polycycloalkane is directly fused to the core or fused to a substituent of the core.

SUBSTITUTED PARA-BIPHENYLOXYMETHYL DIHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF

The present invention relates to a series of substituted para-biphenyloxymethyl dihydro oxazolopyrimidinones of formula (I) as defined herein. This invention also relates to methods of making these compounds including novel intermediates. The compounds of

Regioselective haloaromatization of 1,2-bis(ethynyl)benzene via halogen acids and PtCl2. Platinum-catalyzed 6-π electrocyclization of 1,2-bis(1′-haloethenyl)benzene intermediates

Treatment of 1,2-bis(ethynyl)benzene (1) with aqueous HX (X = Br, I) in hot 3-pentanone (100-105 °C, 2 h) afforded 1,2-bis(1′-haloethenyl)benzene species 2-Br and 2-I in 98% and 95% yields, respectively. The hydrochlorination of endiyne 1 failed to proceed at elevated temperature but was implemented efficiently by PtCl2 (5 mol %) in hot 3-pentanone (100 °C, 2 h) to give 1,2-bis(1′-chloroetheny)benzene 2-Cl in 80% yield. In the presence of PtCl2 (5 mol %), these halides 2-Cl, 2-Br, and 2-I were subsequently converted to 1-halonaphthalenes 3-Cl, 3-Br, and 3-I in the mother solution via sequential 6-π electrocyclization and dehalogenation reactions. PtCl2 (5 mol %) also effected direct haloaromatization of endiyne 1 with HX (X = Cl, Br, I) and gave 1-halonaphthalenes 3-Cl, 3-Br, and 3-I in 64-71% yields. This investigation reports the scope and the regioselectivity of haloaromatization of various enediynes catalyzed by PtCl2.