61347-76-0

Basic information

• Product Name: NH-benzyl-(1R,2S)-norephedrine
• Synonyms: NH-benzyl-(1R,2S)-norephedrine
• CAS NO: 61347-76-0
• Molecular Weight: 241.333
• Mol File: 61347-76-0.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: NH-benzyl-(1R,2S)-norephedrine(CAS DataBase Reference)
• NIST Chemistry Reference: NH-benzyl-(1R,2S)-norephedrine(61347-76-0)
• EPA Substance Registry System: NH-benzyl-(1R,2S)-norephedrine(61347-76-0)

Safety Data

• Hazardous Substances Data: 61347-76-0(Hazardous Substances Data)

Upstream product

• 492-41-1 (1R,2S)-norephedrine 
• 100-39-0 benzyl bromide 
• 2114-00-3 2-bromo-1-phenyl-1-propanone 
• 100-46-9 benzylamine 
• 25438-37-3 phenyl(trimethylsiloxy)acetonitrile 
• 532-28-5 (RS)-mandelonitrile 
• 100-52-7 benzaldehyde 
• 698352-11-3 2-(N-benzyl-N-tert-butoxycarbonylamino)-1-phenyl-1-propanone 
• 698351-56-3 benzyl-(2-hydroxy-1-methyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester 
• 52597-17-8 2-(N-benzylamino)-1-phenyl-1-propanone 
• 64-17-5 ethanol 
• 90-63-1 (RS)-1-hydroxy-1-phenylpropan-2-one 
• 1798-60-3 (R)-1-hydroxy-1-phenyl-2-propanone 
• 67-56-1 methanol 

Downstream Products

• 90-85-7 (1R,2S)-1-phenyl-2-(N-methyl-N-benzylamino)propan-1-ol 
• 198906-14-8 (2R,4S,5R)-2-Chloro-3-benzyl-4-methyl-5-phenyl-1,3,2-oxazaphospholidin-2-one 
• 613688-63-4 [benzyl[(1S,2R)-2-chloro-1-methyl-2-phenylethyl]amino]acetonitrile 
• 613688-64-5 (2S,3S,4S)-1-benzyl-4-methyl-3-phenylazetidine-2-carbonitrile 
• 613688-75-8 (S)-2-[((2R,3S,4S)-1-Benzyl-4-methyl-3-phenyl-azetidine-2-carbonyl)-amino]-propionic acid methyl ester 
• 613688-74-7 (S)-2-[((2S,3S,4S)-1-Benzyl-4-methyl-3-phenyl-azetidine-2-carbonyl)-amino]-propionic acid methyl ester 
• 492-41-1 (1R,2S)-norephedrine 
• 190724-40-4 (4S,5S)-3-Benzyl-4-methyl-5-phenyl-oxazolidin-2-one 
• 61347-73-7 (1S,2S)-2-(benzylamino)-1-phenyl-1-propanol 

Relevant articles and documents

Design of a genetic algorithm for the simulated evolution of a library of asymmetric transfer hydrogenation catalysts

A library of catalysts was designed for asymmetric-hydrogen transfer to acetophenone. At first, the whole library was submitted to evaluation using high-throughput experiments (HTE). The catalysts were listed in ascending order, with respect to their performance, and best catalysts were identified. In the second step, various simulated evolution experiments, based on a genetic algorithm, were applied to this library. A small part of the library, called the mother generation (GO), thus evolved from generation to generation. The goal was to use our collection of HTE data to adjust the parameters of the genetic algorithm, in order to obtain a maximum of the best catalysts within a minimal number of gen-erations. It was namely found that simulated evolution's results depended on the selection of GO and that a random GO should be preferred. We also demonstrated that it was possible to get 5 to 6 of the ten best catalysts while investigating only 10% of the library. Moreover, we developed a double algorithm making this result still achievable if the evolution started with one of the worst GO.

Salicylaldehyde based oxazolidines as catalysts for the asymmetric addition of diethylzinc to aldehydes

(Chemical Equation Presented) A series of oxazolidines have been prepared by condensation of N-isopropyl norephedrine with a variety of salicylaldehyde derivatives. Despite the stereochemical relationship of (1R,2S)-norephedrine with (1R,2S)-ephedrine, th

Diastereoselective reduction of α-aminoketones: Synthesis of anti- and syn-β-aminoalcohols

Reduction of N-t-BOC-protected-N-alkyl α-aminoketones with LiEt 3BH or Li(S-Bu)3BH furnishes protected syn-β-aminoalcohols with high selectivities. In contrast, removal of the BOC group followed by reduction of the aminoketone gives anti-β- aminoalcohols with variable selectivities. With aromatic ketones, selectivities are typically high while aliphatic ketones show mediocre to high selectivities depending on steric considerations.