6139-38-4 Usage
General Description
Pyruvaldehyde-bis-thiosemicarbazone, also known as PBT, is a chemical compound that has shown potential as a chelating agent in the treatment of iron overload disorders. It has been studied for its ability to bind and remove excess iron from the body, particularly in patients with thalassemia or other conditions that require frequent blood transfusions. PBT has also demonstrated anti-cancer properties, with research suggesting it may inhibit the growth of certain tumor cells by interfering with their iron metabolism. Additionally, PBT is being investigated for its potential use in magnetic resonance imaging (MRI) as a contrast agent for imaging specific tissues and organs. Overall, the versatile properties of pyruvaldehyde-bis-thiosemicarbazone make it a promising compound for a range of medical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 6139-38-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,1,3 and 9 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 6139-38:
(6*6)+(5*1)+(4*3)+(3*9)+(2*3)+(1*8)=94
94 % 10 = 4
So 6139-38-4 is a valid CAS Registry Number.
InChI:InChI=1/C5H10N6S2/c1-3(9-11-5(7)13)2-8-10-4(6)12/h2H,1H3,(H3,6,10,12)(H3,7,11,13)/b8-2-,9-3-
6139-38-4Relevant articles and documents
Identification of differential anti-neoplastic activity of copper bis(thiosemicarbazones) that is mediated by intracellular reactive oxygen species generation and lysosomal membrane permeabilization
Stefani, Christian,Al-Eisawi, Zaynab,Jansson, Patric J.,Kalinowski, Danuta S.,Richardson, Des R.
, p. 20 - 37 (2015/09/07)
Bis(thiosemicarbazones) and their copper (Cu) complexes possess unique anti-neoplastic properties. However, their mechanism of action remains unclear. We examined the structure-activity relationships of twelve bis(thiosemicarbazones) to elucidate factors
SYNTHESIS OF 1-HALO-1-(ACETYLAMINO)-2-ALKANONES
Zav'yalov, S. I.,Ezhova, G. I.
, p. 1877 - 1881 (2007/10/02)
-
Inhibitors of polyamine biosynthesis VII: Evaluation of pyruvate derivatives as inhibitors of S-adenosyl-L-methionine decarboxylase
Pankaskie,Abdel-Monem
, p. 1000 - 1004 (2007/10/02)
-
