614-51-7Relevant academic research and scientific papers
Conjugated ketone compounds in preventing platelet thrombosis
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, (2008/06/13)
Conjugated ketone compounds of the formula: STR1 wherein Ar is naphthyl, furyl, thienyl, or phenyl optionally bearing one or more substituents selected from the group consisting of chlorine, bromine, C1 -C4 alkyl, C1 -C4 alkoxy, C1 -C4 alkylthio, trifluoromethyl and methylenedioxy, R1 is C1 -C6 alkyl, C3 -C5 alkenyl, C3 -C6 cycloalkyl, C7 -C8 aralkyl or adamantyl, R2 is C1 -C6 alkyl, C3 -C5 alkenyl or C3 -C6 cycloalkyl, or when R1 and R2 are taken together with the nitrogen atom to which they are attached, they form a heterocyclic amino group containing up to 8 carbon atoms, A is straight or branched C1 -C3 alkylene, N-[4-(p-chlorophenyl)-4-oxo-2-trans-butenyl]morpholine and N-[4-(p-methoxyphenyl)-4-oxo-2-trans-butenyl]piperidine being excluded, and their non-toxic salts, which are useful as blood platelet anti-aggregative agents.
