61478-25-9Relevant academic research and scientific papers
Synthesis, molecular modeling and biological evaluations of novel pyrrolidine derivatives as potential cyclooxygenase-2 (COX-2) inhibitors
Chavan, Kamlesh H.,Kedar, Nathrao Ankushrao,Kanhed, Ashish M.,Agrahari, Vishal Kumar,Sinha, Anshuman
, p. 1801 - 1813 (2021)
Abstract: Toward the development of selective cyclooxygenase-2 inhibitors, a series of pyrrolidine derivatives is described. All the compounds containing sulfonamide, ester, nitrile, acid, amide and urea functionalities were computationally screened, and
Nazumazoles A-C, cyclic pentapeptides dimerized through a disulfide bond from the marine sponge theonella swinhoei
Fukuhara, Kazuya,Takada, Kentaro,Okada, Shigeru,Matsunaga, Shigeki
supporting information, p. 2646 - 2648 (2015/06/16)
A mixture of nazumazoles A-C (1-3) was purified from the extract of the marine sponge Theonella swinhoei. The mixture was eluted as an extraordinarily broad peak in the reversed-phase HPLC. The structures of nazumazoles were determined by interpretation o
Synthesis and biological evaluation of selective and potent cyclin-dependent kinase inhibitors
N'Gompaza-Diarra, Joannah,Bettayeb, Karima,Gresh, Nohad,Meijer, Laurent,Oumata, Nassima
, p. 210 - 216 (2013/01/15)
A new series of 2,6,9-trisubstituted purines, structurally related to the cyclin-dependent kinase (CDK) inhibitor Roscovitine, has been synthesized. These compounds mainly differ by the substituent on the C-2 position which encompasses a diol group. These
Synthesis of enantiopure substituted piperidines via an aziridinium ring expansion
Jarvis, Scott B. D.,Charette, Andre B.
supporting information; experimental part, p. 3830 - 3833 (2011/09/16)
Herein we report a novel methodology for the asymmetric synthesis of 3-substituted piperidines from readily available chiral building blocks. This method, which features a novel irreversible dihydropyrole-tetrahydropyridine ring expansion, allows the intr
Total synthesis of (+)-dibromophakellin and (+)-dibromophakellstatin
Imaoka, Takuya,Akimoto, Takafumi,Iwamoto, Osamu,Nagasawa, Kazuo
scheme or table, p. 1810 - 1816 (2011/04/16)
A new method for the preparation of quaternary chiral aminals has been developed that employs an enamide-type Overman rearrangement process. This methodology was applied to enantioselective total syntheses of (+)-dibromophakellin and (+)-dibromophakellstatin.
Evidence for a stereoelectronic effect in human oxygen sensing
Loenarz, Christoph,Mecinovic, Jasmin,Chowdhury, Rasheduzzaman,McNeill, Luke A.,Flashman, Emily,Schofield, Christopher J.
scheme or table, p. 1784 - 1787 (2009/09/07)
How PHDs achieve specificity: trans-4-prolyl hydroxylation of the transcription factor HIF occurs with stereochemical retention. Substrate-analogue studies show how the von Hippel Lindau tumor suppressor protein (pVHL) and the oxygen-sensing hydroxylases (PHDs) achieve specificity for hydroxy prolyl/prolyl residues for the C4-exo/endo prolyl conformations, respectively.
Chiral azabicyclo-N-oxyls mediated enantioselective electrooxidation of sec-alcohols
Shiigi, Hirofumi,Mori, Hiroyuki,Tanaka, Tomoaki,Demizu, Yosuke,Onomura, Osamu
, p. 5247 - 5251 (2008/12/22)
Enantiomerically pure azabicyclo-N-oxyls were prepared from l-hydroxyproline. They mediated enantioselective electrooxidation of racemic sec-alcohols to afford optically active sec-alcohols with moderate to high s value (up to 21).
Design and synthesis of APTCs (aminopyrrolidinetricarboxylic acids): Identification of a new group III metabotropic glutamate receptor selective agonist
Schann, Stephan,Menet, Christel,Arvault, Paul,Mercier, Geraldine,Frauli, Melanie,Mayer, Stanislas,Hubert, Nadia,Triballeau, Nicolas,Bertrand, Hugues-Olivier,Acher, Francine,Neuville, Pascal
, p. 4856 - 4860 (2007/10/03)
A new family of mGlu receptor orthosteric ligands called APTCs was designed and synthesized using a parallel chemistry approach. Amongst 65 molecules tested on mGlu4, mGlu6 and mGlu8 subtypes, (2S,4S)-4-amino-1-[(E)-3-carboxyacryloyl]pyrrolidine-2,4-dicar
The first asymmetric synthesis of (2S,3S,4R)-3-amino-2-hydroxymethyl-4- hydroxypyrrolidine
Curtis, Kim L.,Fawcett, John,Handa, Sandeep
, p. 5297 - 5300 (2007/10/03)
The novel (2S,3S,4R)-3-amino-2-hydroxymethyl-4-hydroxypyrrolidine 5 has been produced in an efficient synthesis from trans-4-hydroxy-l-proline 8. The key step involves a tethered aminohydroxylation of the alkene 7 to introduce regio- and stereoselectively
TRANS PYRROLIDINYL DERIVATIVES AND THEIR PHARMACEUTICAL USE
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Page/Page column 42, (2010/02/15)
The present invention relates to the use of trans pyrrolidinyl of the formula (I) or (II) in which: R1, R2or R3 are hydrogen or a carboxy or amino protecting group; R4 to R8 represent hydrogen or an a
