615-34-9

Basic information

• Product Name: methyl (2S)-2,3-dihydroxypropanoate
• Synonyms: Methyl (2S)-2,3-dihydroxypropanoate; methyl (S)-glycerate; propanoic acid, 2,3-dihydroxy-, methyl ester, (2S)-
• CAS NO: 615-34-9
• Molecular Formula: C₄H₈O₄
• Molecular Weight: 120.1039
• Mol File: 615-34-9.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 241.499°C at 760 mmHg
• Flash Point: 103.748°C
• Density: 1.285g/cm³
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.456
• CAS DataBase Reference: methyl (2S)-2,3-dihydroxypropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2S)-2,3-dihydroxypropanoate(615-34-9)
• EPA Substance Registry System: methyl (2S)-2,3-dihydroxypropanoate(615-34-9)

Safety Data

• Hazardous Substances Data: 615-34-9(Hazardous Substances Data)

Usage

General Description

Methyl (2S)-2,3-dihydroxypropanoate, also known as L-methyl lactate, is a chemical compound with the molecular formula C4H8O4. It is a colorless liquid with a sweet odor, often used as a flavoring agent and fragrance ingredient. It is commonly produced through the esterification of lactic acid with methanol. L-methyl lactate is used in various industries including food and beverage, pharmaceuticals, and cosmetics, and is often utilized as a solvent or a component in skincare and personal care products. It is considered to be relatively safe for use in these applications, although it should be handled and stored with proper precautions due to its potential irritant properties.

Upstream product

• 67-56-1 methanol 
• 67525-74-0 (+/-)-calcium glycerate dihydrate 
• 56-81-5 glycerol 
• 108865-84-5 methyl 2,2-dimethyl-1,3-dioxolane-4-carboxylate 
• 473-81-4 glyceric acid 
• 186581-53-3 diazomethane 
• 292638-85-8 acrylic acid methyl ester 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 137618-50-9 2,3-dihydroxy-N,N-dimethylpropionamide 
• 108865-84-5 methyl 2,2-dimethyl-1,3-dioxolane-4-carboxylate 
• 3674-09-7 methyl 2,3-dichloropropionate 
• 4093-54-3 methyl-(1,1,2,2,3-pentachloro-propyl)-ether 
• 173105-57-2 (+/-)-methyl 3-(tert-butyldiphenylsilyloxy)-2-hydroxypropanoate 
• 141-76-4 3-iodopropanoic acid 
• 60456-21-5 methyl (4S)-2,2-dimethyl-1,3-dioxolane-4-carboxylate 
• 52373-72-5 methyl (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate 
• 227097-96-3 (E)-3-(3,4-Diacetoxy-phenyl)-acrylic acid 2-[(E)-3-(3,4-diacetoxy-phenyl)-acryloyloxy]-1-methoxycarbonyl-ethyl ester 
• 5694-00-8 glycidamide 
• 93306-88-8 methyl 2-benzyloxy-3-hydroxypropionate 
• 98291-97-5 methyl 2-hydroxy-3-(benzyloxy)propionate 
• 124579-79-9 methyl 3-(triphenylmethyl)glycerate 
• 471246-98-7 2-Benzyloxymethyl-[1,3]dioxolane-4-carboxylic acid methyl ester 

Relevant articles and documents

Concise Asymmetric Synthesis of Kweichowenol A

An asymmetric 11-step synthesis of the polyoxygenated cyclohexene natural product kweichowenol A from the traditional Chinese medicinal herb Uvaria kweichowesis is reported. The oxygenation pattern was installed on a linear precursor by exploiting the acyclic stereocontrol of the Kiyooka aldol reaction, as well as Cram chelate-controlled Grignard reactions. Ring-closing metathesis and a selective benzoylation then gave the natural product.

Dihydroxylation of Olefins with Potassium Permanganate Catalyzed by Imidazolium Salt

The development of an efficient and cost-effective cis -dihydroxylation reaction of acrylate derivatives was achieved. The reaction proceeded in acetone with an imidazolium salt as catalyst to furnish the dihydroxylation of olefins at 0-5 °C using KMnO 4 as the oxidant. This efficient and non-aqueous protocol was highly suitable for the large-scale preparation of cis -dihydroxylated compounds from the corresponding acrylate derivatives in high yields without overoxidation.

NOVEL PYRAZOLO PYRIMIDINE DERIVATIVES AND THEIR USE AS MALT1 INHIBITORS

The present invention describes new pyrazolo-pyrimidine derivatives of formula (I) or a pharmaceutically acceptable salt thereof; (I) wherein, R1 is halogen, cyano, or C1-C3alkyl optionally substituted by halogen; R2 is C1-C6alkyl optionally substituted one or more times by C1-C6alkyl, C2-C6alkenyl, hydroxyl, N,N-di-C1-C6alkyl amino, N-mono-C1-C6alkyl amino, O-Rg, Rg, phenyl, or by C1-C6alkoxy wherein said alkoxy again may optionally be substituted by C1-C6alkoxy, N,N-di-C1-C6alkyl amino, Rg or phenyl; C3-C6cycloalkyl optionally substituted by C1-C6alkyl, N,N-di-C1-C6alkyl amino or C1-C6alkoxy-C1-C6alkyl, and/or two of said optional substituents together with the atoms to which they are bound may form an annulated or spirocyclic 4 - 6 membered saturated heterocyclic ring comprising 1 - 2 O atoms; phenyl optionally substituted by C1-C6alkoxy; a 5 - 6 membered heteroaryl ring having 1 to 3 heteroatoms selected from N and O said ring being optionally substituted by C1-C6alkyl which may be optionally substituted by amino or hydroxy; Rg; or N,N-di-C1-C6alkyl amino carbonyl; and R is phenyl independently substituted two or more times by Ra, 2-pyridyl independently substituted one or more times by Rb, 3-pyridyl independently substituted one or more times by Rc, or 4-pyridyl independently substituted one or more times by Rd; which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.