820976-77-0Relevant articles and documents
Synthesis of 5-substituted-1H-indol-2-yl-1H-quinolin-2-ones: A novel class of KDR kinase inhibitors
Kuethe, Jeffrey T.,Wong, Audrey,Qu, Chuanxing,Smitrovich, Jacqueline,Davies, Ian W.,Hughes, David L.
, p. 2555 - 2567 (2007/10/03)
(Chemical Equation Presented) A number of approaches for the synthesis of the 1H-indol-2-yl-1H-quinolin-2-one ring system found in the potent and selective KDR kinase inhibitor 1 are described. The preparation and reaction of trimethylsilylnitrobenzene 26