820976-77-0

Upstream product

• 328058-21-5 4-(4-(methanesulfonyl)piperazin-1-yl-methyl)aniline 
• 615552-65-3 1-(methylsulfonyl)-4-{4-nitro-3-[(trimethylsilyl)methyl]benzyl}piperazine 
• 423747-61-9 1-(methanesulfonyl)-4-(4-nitrobenzyl)piperazine 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 139549-06-7 2-methoxy-3-quinolinecarboxyaldehyde 
• 58198-49-5 1-(4-nitrobenzyl)piperazine 
• 42580-44-9 4-Amino-3-bromobenzaldehyde 
• 73568-25-9 2-chloro-3-quinoline carboxaldehyde 
• 55276-43-2 4-methanesulfonylpiperazine 
• 850171-04-9 2-bromo-4-(4-methanesulfonylpiperazin-1-ylmethyl)aniline 
• 850171-39-0 2-methoxy-3-vinylquinoline 
• 796854-51-8 2-[5-(4-methanesulfonyl-piperazin-1-yl-methyl)-2-nitrophenyl]-1-(2-methoxyquinolin-3-yl)-ethanol 

Relevant academic research and scientific papers

Synthesis of 5-substituted-1H-indol-2-yl-1H-quinolin-2-ones: A novel class of KDR kinase inhibitors

(Chemical Equation Presented) A number of approaches for the synthesis of the 1H-indol-2-yl-1H-quinolin-2-one ring system found in the potent and selective KDR kinase inhibitor 1 are described. The preparation and reaction of trimethylsilylnitrobenzene 26

SUBSTITUTED INDOLES AND A PROCESS FOR PREPARING SUBSTITUTED INDOLES

The instant invention is directed to novel compounds of Formulae (I) and (II), as wells a process for preparing compounds of Formula (II). The process comprises a palladium-catalyzed reductive cyclization of a compound of Formula (I) to produce a compound of Formula (II).