423747-61-9

Basic information

• Product Name: Piperazine, 1-(methylsulfonyl)-4-[(4-nitrophenyl)methyl]-
• CAS NO: 423747-61-9
• Molecular Formula: C12H17N3O4S
• Molecular Weight: 299.351
• Mol File: 423747-61-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Piperazine, 1-(methylsulfonyl)-4-[(4-nitrophenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1-(methylsulfonyl)-4-[(4-nitrophenyl)methyl]-(423747-61-9)
• EPA Substance Registry System: Piperazine, 1-(methylsulfonyl)-4-[(4-nitrophenyl)methyl]-(423747-61-9)

Safety Data

• Hazardous Substances Data: 423747-61-9(Hazardous Substances Data)

Upstream product

• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 58198-49-5 1-(4-nitrobenzyl)piperazine 
• 124-63-0 methanesulfonyl chloride 
• 55276-43-2 4-methanesulfonylpiperazine 

Downstream Products

• 796854-51-8 2-[5-(4-methanesulfonyl-piperazin-1-yl-methyl)-2-nitrophenyl]-1-(2-methoxyquinolin-3-yl)-ethanol 
• 850171-27-6 1-(2-chloroquinolin-3-yl)-2-(5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-2-nitrophenyl)ethanone 
• 850171-14-1 2-[5-(4-methanesulfonylpiperazin-1-ylmethyl)-2-nitrophenyl]-1-(2-chloroquinolin-3-yl)ethanol 
• 850171-48-1 trans-3-{2-[5-(4-methanesulfonylpiperazin-1-ylmethyl)-2-nitrophenyl]vinyl}-2-chloroquinoline 
• 820976-77-0 trans-3-{2-[5-(4-methanesulfonylpiperazin-1-ylmethyl)-2-nitrophenyl]vinyl}-2-methoxyquinoline 
• 863969-66-8 2-[5-(4-methanesulfonyl-piperazin-1-ylmethyl)-2-nitro-phenyl]-1-quinolin-3-yl-ethanol 
• 850171-46-9 trans-3-{2-[5-(4-methanesulfonylpiperazin-1-ylmethyl)-2-nitrophenyl]vinyl}quinoline 
• 850171-04-9 2-bromo-4-(4-methanesulfonylpiperazin-1-ylmethyl)aniline 
• 328058-21-5 4-(4-(methanesulfonyl)piperazin-1-yl-methyl)aniline 
• 615552-65-3 1-(methylsulfonyl)-4-{4-nitro-3-[(trimethylsilyl)methyl]benzyl}piperazine 
• 615552-45-9 2-[trans-2-(5-{[4-(methanesulfonyl)piperazin-1-yl]methyl}-2-nitrophenyl)vinyl]-1-(phenylsulfonyl)-1H-indole 
• 793675-34-0 N³-cyclohexyl-N²-(4-{[4-(methylsulfonyl)piperazin-1-yl]methyl}phenyl)pyridine-2,3-diamine 

Relevant articles and documents

Synthesis of an indole containing KDR kinase inhibitor by tandem Sonogashira coupling-5-endo-dig-cyclization as a key step

An efficient synthesis of the potent KDR kinase inhibitor 3-[5-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-1H-indol-2-yl]quinoline-2-(1H)-one using a Sonogashira coupling-5-endo-dig-cyclization strategy is described.

Synthesis of disubstituted imidazo[4,5-b]pyridin-2-ones

Regioselective palladium-catalyzed amination of 2-chloro-3-iodopyridine followed by a subsequent palladium-catalyzed amination leads to 2,3-diaminopyridines. Treatment with triphosgene affords highly functionalized unsymmetrical imidazo [4,5-b] pyridin-2-

Effective strategy for the preparation of indolocarbazole aglycons and glycosides: Total synthesis of tjipanazoles B, D, E, and I

(Matrix presented) An effective strategy has been developed for the rapid and efficient preparation of ortho-nitrostyrenes, which can be converted to unsymmetrical 2,2′-biindoles. A unique condensation of these 2,2′-biindoles with (dimethylamino)-acetalde