77744-52-6

Basic information

• Product Name: Syncarpic acidSee
• CAS NO: 77744-52-6
• Molecular Weight: 182.219
• Mol File: 77744-52-6.mol

Chemical Properties

• CAS DataBase Reference: Syncarpic acidSee(CAS DataBase Reference)
• NIST Chemistry Reference: Syncarpic acidSee(77744-52-6)
• EPA Substance Registry System: Syncarpic acidSee(77744-52-6)

Safety Data

• Hazardous Substances Data: 77744-52-6(Hazardous Substances Data)

Upstream product

• 480-66-0 2,4,6-trihydroxyacetophenone 
• 124-41-4 sodium methylate 
• 74-88-4 methyl iodide 
• 7073-22-5 4-acetyl-5-hydroxy-2,2,6,6-tetramethyl-cyclohex-4-ene-1,3-dione 

Downstream Products

• 92735-06-3 5-Hydroxy-2,2,6,6-tetramethyl-4-pyrrolidin-2-yl-cyclohex-4-ene-1,3-dione 
• 54247-21-1 5-hydroxy-2,2,6,6-tetramethyl-4-(2-methyl-1-(2,4,6-trihydroxy-3-(1-(2-hydroxy-3,3,5,5-tetramethyl-4,6-dioxocyclohex-1-enyl)-2-methylpropyl)-5-isobutyrylphenyl)propyl)cyclohex-4-ene-1,3-dione 
• 1083197-75-4 5-hydroxy-2,2,6,6-tetramethyl-4-(3-methyl-1-(2,4,6-trihydroxy-3-isobutyrylphenyl)butyl)cyclohex-4-ene-1,3-dione 
• 61565-12-6 2,2,4,4-tetramethyl-6-(2-methylpropylidene)-cyclohexane-1,3,5-trione 
• 114751-23-4 5-hydroxy-2,2,6,6-tetramethyl-4-(2-methylprop-1-en-yl)cyclohex-4-ene-1,3-dione 
• 83814-56-6 3-hydroxy-2-(2-methyl-1-piperidino)propyl-4,4,6,6-tetramethylcyclohex-2-ene-1,5-dione 
• 114751-25-6 2,2,4,4-Tetramethyl-6-(2-methyl-1-pyrrolidin-1-yl-propyl)-cyclohexane-1,3,5-trione 

Relevant articles and documents

Isolation and biomimetic total synthesis of tomentodiones A-B, terpenoid-conjugated phloroglucinols from the leaves of: Rhodomyrtus tomentosa

Tomentodiones A (1) and B (2), a pair of C-11′ epimers of caryophyllene-conjugated phloroglucinols with an unprecedented skeleton, were isolated from the leaves of Rhodomyrtus tomentosa. Their structures were elucidated through the application of extensiv

Rhodomentones A and B, novel meroterpenoids with unique NMR characteristics from: Rhodomyrtus tomentosa

Two novel meroterpenoids, rhodomentones A and B bearing an unprecedented caryophyllene-conjugated oxa-spiro[5.8] tetradecadiene skeleton, were isolated from the leaves of Rhodomyrtus tomentosa. Their structures with unique NMR characteristics were determi

Total syntheses of ericifolione and its analoguesviaa biomimetic inverse-electron-demand Diels-Alder reaction

Driven by bioinspiration and appreciation of the structure of ericifolione, a biomimetic tautomerization/intermolecular inverse-electron-demand hetero Diels-Alder reaction cascade sequence promoted by sodium acetate to rapidly construct sterically hindere

Mn(III)-catalyzed aerobic oxidation of 2-alkenyl-1,3-diketone enols. Synthesis of 1,2-dioxin-3-ols and natural phytohormone G factors

The Mn(III)-catalyzed aerobic oxidation of 2-alkenyl-1,3-diketone enols is described. The reaction produced unsaturated endoperoxides, i.e., 1,2-dioxin-3-ols, via resonance stabilized alkenyldiketone radicals. This convenient and eco-friendly reaction was

Application of myrtle ketone compound in preparation of novel coronavirus SARS-CoV-2 medicine

The invention discloses application of myrtle ketone compounds in preparation of novel coronavirus SARS-CoV-2 medicaments. The myrtle ketone compound has obvious inhibition effect on novel coronavirus SARS-CoV-2. Mechanisms include, but are not limited to, inhibition of new coronavirus SARS-CoV-2 into cells, preventing the replication of new coronavirus SARS-CoV-2 in the host cell, and timely modulating apoptosis of infected cells. To the myrtle ketone compound provided by the invention, the novel coronavirus SARS-CoV-2 has a remarkable inhibiting effect, and the cytotoxicity is relatively small. It can therefore be used for the prophylaxis or treatment of neoplastic pneumonitis. The invention is expected to provide new candidate drug molecules for clinic treatment of nebrodensis.

Peachy ketones and their application in the preparation of anti-flu virus drugs

The present invention discloses myrtle ketone compounds and their applications in the preparation of anti-influenza virus drugs. The myrtle ketone compounds of the present invention have a significant inhibitory effect on influenza viruses, the mechanism of action of which includes (but is not limited to) inhibiting influenza viruses entering cells, preventing the replication of influenza viruses in host cells, and timely regulating the apoptosis program of infected cells. The myrtle ketone compounds provided by the present invention have inhibitory effects on both influenza A and B viruses, the activity is better than the positive drug ribavirin (Ribavrin), and therefore can be used to prevent or treat influenza. The present invention is expected to provide a new active lead compound or drug candidate molecule for the clinical treatment of influenza.

The Biomimetic Total Syntheses of the Antiplasmodial Tomentosones A and B

The first biomimetic total syntheses of natural phloroglucinols tomentosones A and B and their analogues have been accomplished. The synthetic strategy primarily referred to the potential biosynthetic precursors and their possible sequence of segments ass

The First Racemic Total Syntheses of the Antiplasmodials Watsonianones A and B and Corymbone B

The first biomimetic total syntheses of three biologically meaningful acylphloroglucinols, watsonianones A and B and corymbone B, with potent antiplasmodial activity, were performed. Their total syntheses were carried out through a diversity-oriented synthetic strategy from congener 2,2,4,4-tetramethyl-6-(3-methylbutylidene)cyclohexane-1,3,5-trione with high step efficiency. The spontaneous enolization/air oxidation of the precursor 2,2,4,4-tetramethyl-6-(3-methylbutylidene)cyclohexane-1,3,5-trione through a singlet O2-induced Diels-Alder reaction pathway to assemble the key biosynthetic peroxide intermediate is also discussed.

Method for synthesizing anti-malarial drug watsonianones A

The invention discloses a method for synthesizing an anti-malarial drug watsonianones A. The method comprises the following steps: carrying out a Knoevenagel reaction catalyzed by proline on syncarpicacid and isovaleraldehyde to obtain a precursor compoun

Isolation and Synthesis of Novel Meroterpenoids from Rhodomyrtus tomentosa: Investigation of a Reactive Enetrione Intermediate

Rhodomyrtusials A–C, the first examples of triketone-sesquiterpene meroterpenoids featuring a unique 6/5/5/9/4 fused pentacyclic ring system were isolated from Rhodomyrtus tomentosa, along with several biogenetically-related dihydropyran isomers. Two bis-furans and one dihydropyran isomer showed acetylcholinesterase (AChE) inhibitory activity. Structures of the isolates were unambiguously established by a combination of spectroscopic data, ECD analysis, and total synthesis. Bioinspired total syntheses of six isolates were achieved in six steps utilizing a reactive enetrione intermediate generated in situ from a readily available hydroxy-endoperoxide precursor.