61593-04-2

Upstream product

• 507-20-0 tertiary butyl chloride 
• 6630-33-7 ortho-bromobenzaldehyde 
• 2259-30-5 tert-butylmagnesium bromide 
• 18982-54-2 o-bromobenzyl alcohol 
• 594-19-4 tert.-butyl lithium 
• 61593-14-4 1-(2-bromophenyl)-2,2-dimethyl-propan-1-one 
• 7154-66-7 2-bromobenzoic acid chloride 

Downstream Products

• 61593-14-4 1-(2-bromophenyl)-2,2-dimethyl-propan-1-one 
• 500898-93-1 (RS,RS)-Bis[2-(2,2-dimethyl-1-hydroxypropyl)phenyl] diselenide 
• 61593-05-3 1-(2-Bromo-phenyl)-2,2-dimethyl-1-phenyl-propan-1-ol 
• 23450-18-2 2-benzyl-1-bromobenzene 
• 61593-15-5 1-(2-Bromphenyl)-1-phenyl-2,2-dimethylpropan 
• 61592-95-8 1-Bromo-2-(1,1-dimethyl-2-phenyl-propyl)-benzene 
• 61592-94-7 1-Bromo-2-(1,2-dimethyl-2-phenyl-propyl)-benzene 
• 61592-97-0 C₁₇H₁₉AsCl₂ 
• 61592-96-9 C₁₇H₁₉Cl₂P 

Relevant academic research and scientific papers

The intramolecular reaction of acetophenoneN-tosylhydrazone and vinyl: Br?nsted acid-promoted cationic cyclization toward polysubstituted indenes

In the presence of TsNHNH2, a Br?nsted acid-promoted intramolecular cyclization ofo-(1-arylvinyl) acetophenone derivatives was developed, leading to polysubstituted indenes with complexity and diversity in moderate to excellent yields. In sharp contrast with either the radical or carbene involved cyclization of aldehydicN-tosylhydrazone with vinyl, a cationic cyclization pathway was involved, whereN-tosylhydrazone served as an electrophile and alkylation reagent during this transformation.

Enantiopurity and absolute configuration determination of arene cis-dihydrodiol metabolites and derivatives using chiral boronic acids

The relative merits of the methods employed to determine enantiomeric excess (ee) values and absolute configurations of chiral arene and alkene cis-1,2-diol metabolites, including boronate formation, using racemic or enantiopure (+) and (?)-2-(1-methoxyet

Diisobutylaluminum hydride-promoted cyclization of benzyl and phenylsilyl ethers bearing a 2-(trimethylsilyl)ethynyl group: syntheses of indenes and benzosiloles

The reaction of o-[2-(trimethylsilyl)ethynyl]benzyl methyl ethers with diisobutylaluminum hydride (DIBAL-H) gave 2-(trimethylsilyl)indenes in good yields. This cyclization proceeds by regio- and stereoselective hydroalumination of the alkyne moiety followed by intramolecular nucleophilic substitution. o-[2-(Trimethylsilyl)ethynyl]phenylsilyl methyl ethers also underwent the DIBAL-H promoted-cyclization to be converted into 2-(trimethylsilyl)benzosiloles in good yields. This approach provides straightforward and efficient way to construct benzosiloles from readily available organosilanes.

Synthesis of 1-indanols and 1-indanamines by intramolecular palladium(0)-catalyzed C(sp3)-H arylation: Impact of conformational effects

A range of valuable 1-indanols and 1-indanamines containing a tertiary C1 atom were synthesized by intramolecular palladium(0)-catalyzed C(sp 3)-H arylation, despite unfavorable steric interactions. The efficiency of the reaction was found to correlate with the degree of substitution at C2, as expected from the Thorpe-Ingold effect. Additionally, the nature of the heteroatomic substituent at C1 had a marked influence on the diastereoselectivity at C1 and C2; indeed, 1-indanols and 1-indanamines were obtained with the opposite relative configuration. Analysis of the X-ray and DFT-optimized structures of the corresponding reactive intermediates provided useful insights into the subtle conformational effects induced by these substituents.