30148-17-5

Basic information

• Product Name: (1-METHYL-1H-IMIDAZOL-2-YL)-PHENYL-METHANONE
• Synonyms: (1-METHYL-1H-IMIDAZOL-2-YL)-PHENYL-METHANONE;2-BENZOYL-1-METHYLIMIDAZOLE;AKOS BBS-00002809;Methanone, (1-methyl-1H-imidazol-2-yl)phenyl-;2-benzoyl-1-Methyl-1H-iMidazole;(1-methylimidazol-2-yl)-phenylmethanone
• CAS NO: 30148-17-5
• Molecular Formula: C₁₁H₁₀N₂O
• Molecular Weight: 186.21
• Mol File: 30148-17-5.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 353.254°C at 760 mmHg
• Flash Point: 167.442°C
• Appearance: /
• Density: 1.13
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.594
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (1-METHYL-1H-IMIDAZOL-2-YL)-PHENYL-METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: (1-METHYL-1H-IMIDAZOL-2-YL)-PHENYL-METHANONE(30148-17-5)
• EPA Substance Registry System: (1-METHYL-1H-IMIDAZOL-2-YL)-PHENYL-METHANONE(30148-17-5)

Safety Data

• Hazardous Substances Data: 30148-17-5(Hazardous Substances Data)

Usage

General Description

"(1-Methyl-1H-imidazol-2-yl)-phenyl-methanone" is a synthetic chemical compound formulated from imidazole and derived compounds. Imidazole rings are commonly found in vital biological compounds, including amino acids, enzymes, and the nucleotides of DNA. Therefore, "(1-Methyl-1H-imidazol-2-yl)-phenyl-methanone", as an imidazole derivative, could have significant applications in medicinal chemistry, biochemistry, and pharmaceutical research. Its exact properties, toxicity, and potential uses would need to be determined through further scientific investigation. Currently, this compound is not commercially available and is typically used for research purposes.

InChI:InChI=1/C11H10N2O/c1-13-8-7-12-11(13)10(14)9-5-3-2-4-6-9/h2-8H,1H3

Upstream product

• 616-47-7 1-methyl-1H-imidazole 
• 93-58-3 benzoic acid methyl ester 
• 3389-54-6 n-benzoylpyrrolidine 
• 98-88-4 benzoyl chloride 
• 51081-36-8 2-lithium-N-methylimidazole 
• 100-47-0 benzonitrile 
• 30517-60-3 (1-methyl-1H-imidazol-2-yl)-phenylmethanol 
• 93-89-0 benzoic acid ethyl ester 
• 92506-23-5 2-benzyl-1-methyl-1H-imidazole 
• 65-85-0 benzoic acid 
• 1266333-81-6 3-methyl-1-[methyl(phenyl)amino]-1H-imidazol-3-ium iodide 
• 100-52-7 benzaldehyde 

Downstream Products

• 30517-58-9 2-(diphenylhydroxymethyl)-1-methyl-1H-imidazole 
• 118415-78-4 2-(1-hydroxy-1-phenyl-3-butenyl)-1-methyl-1H-imidazole 
• 93-58-3 benzoic acid methyl ester 
• 1192573-47-9 pentyl {2-[({[(1-methyl-1H-imidazol-2-yl)(phenyl)methylene]amino}oxy)-methyl]pyrimidin-4-yl}carbamate 
• 1192576-16-1 N-{2-[({[(1-methyl-1H-imidazol-2-yl)(phenyl)methylene]amino}oxy)methyl]pyrimidin-4-yl}cyclopropanecarboxamide 
• 1192572-97-6 2-[({[(1-methyl-1H-imidazol-2-yl)(phenyl)methylene]amino}oxy)methyl]pyrimidin-4-amine 
• 1192575-98-6 N-hydroxy-1-(1-methyl-1H-imidazol-2-yl)-1-phenylmethanimine 
• 129146-31-2 3-Methyl-1-(2-oxo-2-phenyl-ethyl)-2-(1-phenyl-vinyl)-3H-imidazol-1-ium; bromide 
• 111931-07-8 2-(Hydroxy-diphenyl-methyl)-1,3-dimethyl-3H-imidazol-1-ium; iodide 

Relevant articles and documents

Photoenzymatic Hydrogenation of Heteroaromatic Olefins Using ‘Ene’-Reductases with Photoredox Catalysts

Flavin-dependent ‘ene’-reductases (EREDs) are highly selective catalysts for the asymmetric reduction of activated alkenes. This function is, however, limited to enones, enoates, and nitroalkenes using the native hydride transfer mechanism. Here we demonstrate that EREDs can reduce vinyl pyridines when irradiated with visible light in the presence of a photoredox catalyst. Experimental evidence suggests the reaction proceeds via a radical mechanism where the vinyl pyridine is reduced to the corresponding neutral benzylic radical in solution. DFT calculations reveal this radical to be “dynamically stable”, suggesting it is sufficiently long-lived to diffuse into the enzyme active site for stereoselective hydrogen atom transfer. This reduction mechanism is distinct from the native one, highlighting the opportunity to expand the synthetic capabilities of existing enzyme platforms by exploiting new mechanistic models.

Synthesis of 2-aroyl-1-methyl-1H-imidazoles using aryl carboxylic acids

A new and useful reaction for the synthesis of 2-aroyl-1-methyl-1H-imidazoles using free aryl carboxylic acids was developed. This method was applicable to naphthoic acid and benzoic acid derivatives to give each target compound with up to 80% yield.

Enantioselective rhodium/ruthenium photoredox catalysis: en route to chiral 1,2-aminoalcohols

A rhodium-based chiral Lewis acid catalyst combined with [Ru(bpy)3](PF6)2 as a photoredox sensitizer allows for the visible-light-activated redox coupling of α-silylamines with 2-acyl imidazoles to afford, after desilylation, 1,2-amino-alcohols in yields of 69-88% and with high enantioselectivity (54-99% ee). The reaction is proposed to proceed via an electron exchange between the α-silylamine (electron donor) and the rhodium-chelated 2-acyl imidazole (electron acceptor), followed by a stereocontrolled radical-radical reaction. Substrate scope and control experiments reveal that the trimethylsilyl group plays a crucial role in this reductive umpolung of the carbonyl group.