61668-03-9

Upstream product

• 51787-79-2 1,1-bis(-4-fluorophenyl)-4-iodobutane 
• 345-90-4 bis(4-fluorophenyl)methylbromide 
• 762-72-1 allyl-trimethyl-silane 
• 365-24-2 4,4'-difluorobenzhydryl alcohol 
• 345-92-6 4,4'-Difluorobenzophenone 
• 39769-55-6 4,4′-difluorodiphenylmethyl cation 
• 3312-04-7 4-chloro-1,1-bis(4-fluorophenyl)butane 
• 457-68-1 4,4'-difluorodiphenylmethane 
• 19422-37-8 1,1,2,2-tetrakis(4-fluorophenyl)ethane 

Downstream Products

• 2062-78-4 pimozide 
• 51787-79-2 1,1-bis(-4-fluorophenyl)-4-iodobutane 
• 230297-18-4 3,3-di-(4-fluorophenyl)propanal 

Relevant academic research and scientific papers

Silylated cyclopentadienes as competent silicon Lewis acid catalysts

The synthesis and characterization of silicon Lewis acid complexes that incorporate highly electron-deficient cyclopentadienes is reported. Several pentacarboxycyclopentadienyl and monocarboxytetracyanocyclopentadienyl complexes were prepared. A comparison of their reactivities for catalysis of the allylation of an electron-deficient benzaldehyde was established. The use of a monocarboxytetracyano silylium donor was shown to be effective for the allylation or arylation of a variety of electrophiles via an anion abstraction pathway.

Carbenium ion formation by fragmentation of electrochemically generated oxonium ions

Fragmentation of electrochemically generated oxonium ions can be exploited to form carbenium ions at a low oxidation potential in the presence of a nucleophile. The application of this concept is demonstrated for the allylation of carbenium ions generated by the anodic oxidation of stannylmethylethers.

Direct Dehydroxylative Coupling Reaction of Alcohols with Organosilanes through Si-X Bond Activation by Halogen Bonding

The combined use of a halogen bond (XB) donor with trimethylsilyl halide was found to be an efficient cocatalytic system for the direct dehydroxylative coupling reaction of alcohol with various nucleophiles, such as allyltrimethylsilane and trimethylcyanide, to give the corresponding adduct in moderate to excellent yields. Detailed control experiments and mechanistic studies revealed that the XB interaction was crucial for the reaction. The application of this coupling reaction is also described.

Efficient and mild iron-catalyzed direct allylation of benzyl alcohols and benzyl halides with allyltrimethylsilane

An efficient and mild iron-catalyzed direct allylation of benzyl alcohols and benzyl halides with allyltrimethylsilane has been developed. The present reaction would provide an excellent alternative to published methods because of its excellent yields, sustainable catalyst, and mild conditions. Copyright Taylor & Francis Group, LLC.

Direct coupling reaction between alcohols and allyltrimethylsilane catalyzed by phosphomolybdic acid

Phosphomolybdic acid (PMA) is a simple and efficient catalyst for direct coupling reaction of alcohols with allyltrimethylsilane. Direct nucleophilic allylation of alcohol with allyltrimethylsilane proceeds in considerably good yield in the presence of catalytic amount of (0.5 mol %) PMA at room temperature. Copyright

O-Benzenedisulfonimide as a reusable broonsted acid catalyst for hosomi-sakurai reactions

Various acetals or alcohols react with allyl(trimethyl)silane or 1-phenyl-2-(trimethylsilyl)acetylene in the presence of a catalytic amount of the Bronsted acid o-benzenedisulfonimide under mild conditions to give good yields of the corresponding products. The catalyst can be easily recovered and purified for use in further reactions, which has economic and ecological advantages. Georg Thieme Verlag Stuttgart.

Generation of diarylcarbenium ion poolsviaelectrochemical C-H bond dissociation

The "cation pools" of diarylcarbenium ions have been generated by the low-temperature electrochemical oxidation of diphenylmethane derivatives. In addition to diphenylmethanes having various substituents, 9,10-dihydroanthracene, dibenzosuberane, and xanth

Oxidative generation of diarylcarbenium ion pools

(Figure Presented) "Cation pools" of diarylcarbenium ions have been generated by the oxidative C-H bond dissociation of diarylmethanes using anodic oxidation. "Diarylcarbenium ion pools" thus generated react with various nucleophiles, such as allylsilanes

Generation of cations from alkoxides: Allylation of propargyl alcohols

The reaction of alkoxides with boron trichloride results in the generation of cations in the absence of Bronsted acids. The absence of a Bronsted acid can make a difference in subsequent transformations such as allylation reactions. Copyright

Modulators of the human CCR5 receptor. Part 2: SAR of substituted 1-(3,3-diphenylpropyl)-piperidinyl phenylacetamides

SAR and DMPK studies led to the identification of substituted N-alkyl-N-[1-(3,3-diphenylpropyl)piperidin-4-yl]-2-phenylacetamides as potent and orally bioavailable ligands for the human CCR5 chemokine receptor.