457-68-1

Basic information

• Product Name: 4,4'-Difluorodiphenylmethane
• Synonyms: 1-Fluoro-4-(4-fluorobenzyl)benzene;4,4'-Difluorodiphenylamine;Benzene, 1,1'-methylenebis[4-fluoro-;4 4'-DIFLUORODIPHENYLMETHANE 99% (GC);BIS-(4-FLUORPHENYL)-METHAN 99%;Bis(4-fluorophenyl)methane,99%;4,4'-Difluorobenzylbenzene;DFDPM
• CAS NO: 457-68-1
• Molecular Formula: C₁₃H₁₀F₂
• Molecular Weight: 204.22
• EINECS: 207-274-2
• Product Categories: Diphenylmethanes (for High-Performance Polymer Research);Functional Materials;Reagent for High-Performance Polymer Research
• Mol File: 457-68-1.mol
• Article Data: 26

Chemical Properties

• Melting Point: 29-30 °C(lit.)
• Boiling Point: 258-260 °C742 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: clear colorless to yellowish liquid after melting
• Density: 1.145 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.933Pa at 50℃
• Refractive Index: n20/D 1.536(lit.)
• Water Solubility: Insoluble in water.
• BRN: 1956387
• CAS DataBase Reference: 4,4'-Difluorodiphenylmethane(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-Difluorodiphenylmethane(457-68-1)
• EPA Substance Registry System: 4,4'-Difluorodiphenylmethane(457-68-1)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 21/22
• Safety Statements: 28A-24/25
• WGK Germany: 3
• Hazardous Substances Data: 457-68-1(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR COLORLESS TO YELLOWISH LIQUID AFTER MELTING

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

Upstream product

• 462-06-6 fluorobenzene 
• 119-61-9 benzophenone 
• 345-92-6 4,4'-Difluorobenzophenone 
• 98-86-2 acetophenone 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 75-09-2 dichloromethane 
• 352-13-6 4-flourophenylmagnesium bromide 
• 78782-17-9 4,4,5,5-tetramethyl-2-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]-1,3,2-dioxaborolane 
• 352-34-1 4-fluoro-1-iodobenzene 
• 312-33-4 dichloro-bis-(4-fluoro-phenyl)-methane 
• 108-90-7 chlorobenzene 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 101-76-8 4,4'-dichlorodiphenylmethane 
• 365-24-2 4,4'-difluorobenzhydryl alcohol 

Downstream Products

• 350-76-5 bis-(4-fluoro-3-nitro-phenyl)-methane 
• 345-92-6 4,4'-Difluorobenzophenone 
• 665002-73-3 2-(bis(4-fluorophenyl)methyl)-1-phenylbutane-1,3-dione 
• 1584154-78-8 ((bis(4-fluorophenyl)methyl)imino)(methyl)(phenyl)-λ⁶-sulfanone 
• 55095-27-7 bis(4-fluorophenyl)methanamine 
• 365-24-2 4,4'-difluorobenzhydryl alcohol 
• 1135493-65-0 N-[bis(4-fluorophenyl)methyl]benzamide 
• 1451789-84-6 N-[bis(4-fluorophenyl)methyl]-4-nitroaniline 

Relevant articles and documents

Novel process for producing phenyl fluoride, diphenyl ketone fluoride, and derivatives thereof

The invention relates to a novel process for producing phenyl fluoride, diphenyl ketone fluoride, and derivatives thereof, especially the phenyl fluoride and derivatives thereof. The invention especially relates to a novel environment-friendly process for synthesizing phenyl fluoride and diphenyl ketone fluoride, which are the raw materials for preparing polyaryl-ether-ketone PAEK. The invention discloses the method that is more effective and environment-friendly for preparing the compounds through a Friedel-Crafts reaction, and further a more environment-friendly process, and provdies beneficial catalysts. Another object of the present invention is to employ the Friedel-Crafts reaction and adopts the beneficial catalysts, wherein the catalyst can be easily combined with the fluoridation reaction which can be carried out before, or after the Friedel-Crafts reaction. Herein, another object of the invention is to use the catalyst in the Friedel-Crafts reaction, wherein the catalyst can work in both the Friedel-Crafts reaction and the fluoridation reaction.

Super electron donor-mediated reductive desulfurization reactions

The desulfurization of thioacetals and thioethers by a pyridine-derived electron donor is described. This methodology provides efficient access to the reduced products in high yields and does not require the use of transition-metals, elemental alkali-metals, or hydrogen atom donors.

Chlorotrimethylsilane and Sodium Iodide: A Remarkable Metal-Free Association for the Desulfurization of Benzylic Dithioketals under Mild Conditions

A novel metal-free process allowing the reductive desulfurization of various benzylic dithioketals to afford diarylmethane and benzylester derivatives with good to excellent yields is reported. At room temperature, this mild reduction process requires only the use of TMSCl and NaI in CH2Cl2 and tolerates a large variety of functional groups. (Figure presented.).