14080-18-3

Basic information

• Product Name: Pyrimidine, 2-(phenylthio)-
• CAS NO: 14080-18-3
• Molecular Formula: C10H8N2S
• Molecular Weight: 188.253
• Mol File: 14080-18-3.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: Pyrimidine, 2-(phenylthio)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 2-(phenylthio)-(14080-18-3)
• EPA Substance Registry System: Pyrimidine, 2-(phenylthio)-(14080-18-3)

Safety Data

• Hazardous Substances Data: 14080-18-3(Hazardous Substances Data)

Upstream product

• 1722-12-9 2-chloropyrimidine 
• 17314-33-9 tributyltin phenyl sulfide 
• 108-98-5 thiophenol 
• 4595-60-2 2-bromopyrimidine 
• 98-80-6 phenylboronic acid 
• 591-50-4 iodobenzene 
• 131242-36-9 2-sulfanylpyrimidine 
• 100-63-0 phenylhydrazine 
• 882-33-7 diphenyldisulfane 
• 4551-15-9 phenylthiotrimethylsilane 
• 108-86-1 bromobenzene 
• 38111-44-3 phenylzinc(II) bromide 
• 61686-49-5 2-pyrimidylsulfenyl chloride 
• 930-69-8 sodium thiophenolate 

Downstream Products

• 27110-82-3 2-(furan-2-yl)pyrimidine 
• 136-95-8 2-amino-benzthiazole 
• 14080-17-2 2-(benzenesulfonyl)pyrimidine 
• 77232-13-4 2-p-tolyl-pyrimidine 
• 69696-00-0 2,6-Pyrimidine phenyl acetylene 

Relevant articles and documents

Palladium catalyzed bispyrimidine thioether synthesis

The synthesis of sulfur-bridged bispyrimidines via coupling of a halopyrimidine and pyrimidine thiolate anion has been explored utilizing a palladium catalyzed cross coupling reaction. Several reaction parameters including stoichiometry and choice of solv

C[sbnd]S cross-coupling catalyzed by a series of easily accessible, well defined Ni(II) complexes of the type [(NHC)Ni(Cp)(Br)]

The synthesis, characterization and catalytic evaluation of a series of NHC-Ni(II) complexes 1-Ni (-Me), 2-Ni (-nBu) and 3-Ni (-Bn) bearing a phthalimide fragment and a cyclopentadienyl (Cp) ligand is reported. The complexes were evaluated in C

Palladium-catalyzed heteroaryl thioethers synthesis overcoming palladium dithiolate resting states inertness: Practical road to sulfones and NH-sulfoximines

We provide efficient synthetic access to heteroaryl sulfones in two-steps using a simple palladium–1,1′-bis[(diphenyl)phosphanyl]ferrocene catalyst to form in high yields variously functionalized heteroaromatic thioethers. Pyridinyl-containing substrates can be subsequently selectively oxidized into sulfones and NH-sulfoximines by using very mild oxidation conditions with a high functional group tolerance. In the palladium-catalyzed C–S coupling of heteroaromatic thiols, reactivity limitation is attached with electron-deficient thiols. We show that this limitation can be resolved by the successful use of 2-bromoheteroarenes in the C–S coupling. We established herein that this choice of heteroaryl electrophilic reagent in palladium-catalyzed C–S bond formation allows overcoming palladium dithiolate out-of-cycle resting state inertness. This was illustrated in the stoichiometric reactivity study of the palladium dithiolate formed from 4-trifluoromethylbenzen-1-thiol –isolated and characterized by multinuclear NMR and XRD– with both 2-chloropyridine and 2-bromopyridine.