617705-26-7Relevant academic research and scientific papers
Streamlined Symmetrical Total Synthesis of Disorazole B1and Design, Synthesis, and Biological Investigation of Disorazole Analogues
Aujay, Monette,Dherange, Balu D.,Gavrilyuk, Julia,Gu, Christine,Krieger, Johannes,Lin, Baiwei,Munneke, Stefan,Murhade, Ganesh M.,Nicolaou, K. C.,Purcell, James W.,Sandoval, Joseph,Sarvaiaya, Hetal,Subramanian, Parthasarathi,Vourloumis, Dionisios,Zhang, Zhaomei
, p. 15476 - 15487 (2020/10/02)
Taking advantage of the C2-symmetry of the antitumor naturally occurring disorazole B1 molecule, a symmetrical total synthesis was devised with a monomeric advanced intermediate as the key building block, whose three-step conversion to the natural product
SYNTHESIS OF DISORAZOLES AND ANALOGS THEREOF AS POTENT ANTICANCER AGENTS
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, (2019/01/11)
In one aspect, the present disclosure provides disorazole analogs of the formula: Formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.
Synthetic studies toward the disorazoles: Synthesis of a masked northern half of disorazole D1 and a cyclopropane analog of the masked northern half of disorazole A1
Haustedt, Lars Ole,Panicker, Sreeletha B.,Kleinert, Mike,Hartung, Ingo V.,Eggert, Ulrike,Niess, Barbara,Hoffmann
, p. 6967 - 6977 (2007/10/03)
The synthesis of a masked northern half of the natural product disorazole D1 and a cyclopropane analog of the masked northern half of disorazole A1 is described. The synthesis involves in both cases as key steps a Z-selective Wittig olefination and a Sonogashira cross-coupling reaction.
Toward the total synthesis of disorazole A1: Asymmetric synthesis of the masked northern half
Hartung, Ingo V.,Eggert, Ulrike,Haustedt, Lars Ole,Niess, Barbara,Schaefer, Peter M.,Hoffmann, H. Martin R.
, p. 1844 - 1850 (2007/10/03)
The stereoselective synthesis of the masked northern half of the antimitotic natural product disorazole A1 is described involving as key step a Z-selective Wittig olefination of a C1-C11 epoxy aldehyde with a C12-C19 phosphonium iodide.
