61771-75-3Relevant articles and documents
Synthesis of α-hydroxy and α-oxospiranes through ruthenium(II)-catalyzed ring-closing metathesis
Aburel,Romming,Ma,Undheim
, p. 1458 - 1472 (2001)
Efficient methodology for the construction of functionalized spiranes using Ru(II)-catalyzed ring-closing metathesis reactions is described. The substrates were appropriately substituted five-, six- and seven-membered cycloalkanes which were spiroannulate
INHIBITORS OF HISTONE DEACETYLASE USEFUL FOR THE TREATMENT OR PREVENTION OF HIV INFECTION
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Page/Page column 34; 35, (2020/02/23)
The present invention relates to Compounds of Formula (I): Formula (I) and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, R3, Ra, Rb, A and B are as defined herein. The present invention also relates to compositions comprising at least one compound of Formula (I), and methods of using the compounds of Formula (I) for treating or preventing HIV infection in a subject.
Relay Rh(ii)/Pd(0) dual catalysis: Synthesis of α-quaternary β-keto-esters: Via a [1,2]-sigmatropic rearrangement/allylic alkylation cascade of α-diazo tertiary alcohols
Wang, Xian-Xu,Huang, Xiao-Yan,Lei, Sen-Hao,Yang, Fang,Gao, Jin-Ming,Ji, Kegong,Chen, Zi-Sheng
supporting information, p. 782 - 785 (2020/01/29)
A relay Rh(ii)/Pd(0) dual catalysis that enables domino [1,2]-sigmatropic rearrangement/allylic alkylation of α-diazo tertiary alcohols is described. This transformation represents a highly efficient method for the one-pot synthesis of α-quaternary β-keto-esters under mild conditions, in which two separate C-C σ-bonds at the carbenic center were formed in a straightforward manner.
Direct Allylation of Active Methylene Compounds with Allylic Alcohols by Use of Palladium/Phosphine-Borane Catalyst System
Shimizu, Aika,Hirata, Goki,Onodera, Gen,Kimura, Masanari
supporting information, p. 1954 - 1960 (2018/04/11)
The C?C bond formation between active methylene compounds and allylic alcohols has been newly developed by using a palladium complex as a catalyst together with a phosphine-borane ligand. The best phosphine-borane ligand for this direct allylation has bee
Catalytic C?C Bond Formation Using a Simple Nickel Precatalyst System: Base- and Activator-Free Direct C-Allylation by Alcohols and Amines
Sweeney, Joseph B.,Ball, Anthony K.,Smith, Luke J.
supporting information, p. 7354 - 7357 (2018/05/03)
A “totally catalytic” nickel(0)-mediated method for base-free direct alkylation of allyl alcohols and allyl amines is reported. The reaction is selective for monoallylation, uses an inexpensive NiII precatalyst system, and requires no activating reagents to be present.
Enantioselective Palladium-Catalyzed Decarboxylative Allylation of β-Keto Esters Assisted by a Thiourea
Qian, Hua,Gu, Guoxian,Zhou, Qinghai,Lu, Jiaxiang,Chung, Lung Wa,Zhang, Xumu
, p. 51 - 56 (2017/10/06)
Enantioselective intramolecular decarboxylative allylation of β-keto esters catalyzed by a palladium bis(phosphine)-thiourea complex is reported. This procedure is not only effective for β-keto esters, but also effective for β-keto amides. An intermolecular variant of the asymmetric decarboxylative allylation is also established. DFT calculations indicate that an outer-sphere mechanism is viable for the decarboxylative allylation of β-keto esters.
N-Heterocyclic olefins as efficient phase-transfer catalysts for base-promoted alkylation reactions
Blümel, Marcus,Crocker, Reece D.,Harper, Jason B.,Enders, Dieter,Nguyen, Thanh V.
supporting information, p. 7958 - 7961 (2016/07/06)
N-Heterocyclic olefins (NHOs) have very recently emerged as efficient promoters for several chemical reactions due to their strong Br?nsted/Lewis basicities. Here we report the novel application of NHOs as efficient phase-transfer organocatalysts for synt
Construction of functionalized carbocycles having contiguous tertiary carbinol and all-carbon stereogenic centers
Reddy, Chennakesava,Babu, Srinivasarao Arulananda,Aslam, Nayyar Ahmad,Rajkumar, Vadla
, p. 2362 - 2380 (2013/05/22)
A highly stereoselective protocol is reported for customizing functionalized carbocyclic building blocks (β-hydroxy esters) and bicyclic lactones with a stereoarray that contains contiguous tertiary carbinol and all-carbon stereocenters. The efficient asymmetric induction and diastereofacial selective addition of allyl and propargyl indiums to hindered α,α-disubstituted cycloalkanones is presented. The stereochemistry of representative products was unequivocally established from single-crystal X-ray crystal structure analyses, and a plausible reaction pathway was proposed to support the high diastereofacial selectivity.
Environmentally-benign palladium(II)-exchanged hydroxyapatite-catalyzed allylic alkylation of allyl methyl carbonate in water
Masuyama, Yoshiro,Nakajima, Yukiko,Okabe, Jun
experimental part, p. 107 - 112 (2011/06/21)
Palladium(II)-exchanged hydroxyapatite (PdHAP; for example, PdHAP-B has a Pd/Ca ratio = ca 1/200) was prepared by ion-exchanging with Ca2+ from calcined hydroxyapatite and Pd(NO3)2 in water at 70 °C for 24 h. The ion-exchange was revealed by inductively coupled plasma analysis; Pd2+ was almost absent in any filtrate that included over 1.6 equimolar amounts of Ca2+ relative to the amount of Pd 2+ consumed. The PdHAP (1 mol% Pd) functioned as a catalyst for the allylic alkylation of allyl methyl carbonate with active methylene compounds such as diethyl malonate, 2-ethoxycarbonylcyclopentanone, 2- ethoxycarbonylcyclohexanone, and 2,2-dimethyl-1,3-dioxane-4,6-dione at 50 °C in water under air. Over 97% of the PdHAP was recovered by centrifugation followed by decantation, and the material could be reused. The catalytic activity of PdHAP accompanied by satisfactory yields of monoallylated products was maintained in ten repetitive uses for the allylic alkylation of allyl methyl carbonate with diethyl malonate at 50 °C for 24 h in water under air. From the standpoints of yield and handling, using water as a solvent was superior to using an organic medium such as ethanol, THF or DMF. Thus, this heterogeneous PdHAP-catalyzed allylic alkylation will be one of the environmentally-benign organic syntheses.
CARBOXYLIC ACID PERI - SUBSTITUTED BICYCLICS FOR OCCLUSIVE ARTERY DISEASE
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Page/Page column 59, (2010/11/08)
Peri-substituted, fused bicyclic ring carboxylic acids useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed.
