6178-26-3

Upstream product

• 1073-67-2 4-vinylbenzyl chloride 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 106-54-7 p-Chlorothiophenol 
• 706-07-0 1-chloro-4-(2-nitrovinyl)benzene 
• 14752-66-0 sodium p-chlorobenzenesulphinate 
• 1615-02-7 3-(4-chlorophenyl)prop-2-enoic acid 
• 1146-44-7 4,4'-dichlorophenyl thiosulfonate 
• 69770-58-7 diethyl<<(p-chlorophenyl)sulfide>methyl>phosphonate 
• 104-88-1 4-chlorobenzaldehyde 
• 40137-12-0 diethyl<<(p-chlorophenyl)sulfonyl>methyl>phosphonate 
• 873-73-4 4-n-chlorophenylacetylene 
• 3405-89-8 2-(4-chloro-phenylsulfonyl)acetic acid 
• 6510-80-1 (4-chloro-phenyl)-(4-chloro-trans-styryl)-sulfide 

Downstream Products

• 1097725-24-0 methyl 4-(4-chlorophenylsulfonyl)-3-(4-chlorophenyl)butyrate 
• 86432-70-4 C₁₅H₁₂Cl₂O₂S 

Relevant academic research and scientific papers

Synthesis of Vinyl Sulfones via I2-mediated Alkene Sulfonylations with Thiosulfonates

A simple sulfonylation strategy involving I2 and thiosulfonates, as sulfonyl-group precursors, is reported for the synthesis of vinyl sulfones. Sulfonyl radicals are presumed to be generated from thiosulfonates, which subsequently react with st

Mn(III)-mediated regioselective synthesis of (: E)-vinyl sulfones from sodium sulfinates and nitro-olefins

An efficient Mn(iii)-mediated coupling reaction of sodium sulfinates with nitro-olefins has been developed, this reaction proceeds in mild and open-flask conditions to afford (E)-vinyl sulfones with high regioselectivities and in good to excellent yields. The control experiments revealed that this transformation could involve a radical process.

Metal-free iodine-mediated synthesis of vinyl sulfones at room temperature using water as solvent

Metal-free efficient iodine-mediated synthesis of vinyl sulfones utilizing aryl sulfinates and alkenes has been realized under mild conditions in water. Notably, sodium methanesulfinate was used in this transformation, affording the β-iodo sulfones in goo

Discovery of vinyl sulfones as a novel class of neuroprotective agents toward Parkinson's disease therapy

Although the etiology of Parkinson's disease (PD) remains elusive, recent studies suggest that oxidative stress contributes to the cascade leading to dopaminergic (DAergic) neurodegeneration. The Nrf2 signaling is the main pathway responsible for cellular defense system against oxidative stress. Nrf2 is a transcription factor that regulates environmental stress response by inducing expression of antioxidant enzyme genes. We have synthesized novel vinyl sulfone derivatives. They exhibited a broad range of activities in inducing HO-1, whose gene expression is under the control of Nrf2. Among them, compound 12g was confirmed to activate Nrf2 and induce expression of the Nrf2-dependent antioxidant enzymes NQO1, GCLC, GLCM, and HO-1, at both mRNA and protein levels in DAergic neuronal cells. This was accompanied by protection of DAergic neurons in both in vitro and MPTP-induced in vivo models of PD. In addition, compound 12g effectively resulted in attenuation of the PD-associated behavioral deficits in the mouse model.

(E)-4-carboxystyrl-4-chlorobenzyl sulfone and pharmaceutical compositions thereof

Pre-treatment with α,β unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone compound to a patient prior to anticancer chemotherapy with a

Styryl sulfone anticancer agents

Styryl sulfone compounds of the invention selectively inhibit proliferation of tumor cells, and induce apoptosis of tumor cells, while sparing normal cells. The compounds, which are useful in the treatment of cancer and other proliferative disorders, have

Styryl sulfone anticancer agents

Styryl sulfone compounds of the invention selectively inhibit proliferation of tumor cells, and induce apoptosis of tumor cells, while sparing normal cells. The compounds, which are useful in the treatment of cancer and other proliferative disorders, have

Reactions of Arenesulfonyl Chlorides with Olefins Catalyzed by a Ruthenium(II) Complex

Arenesulfonyl chlorides react with vinylarenes in the presence of dichlorotris(triphenylphosphine)ruthenium(II) catalyst and 1 molar equiv of a tertiary amine to form α,β-unsaturated sulfones 2.Only the E isomers of the sulfones are formed.In reactions of arenesulfonyl chlorides containing an electron-withdrawing Cl or NO2 substituent with α-methylstyrenes, 2-aryl-3-(arylsulfonyl)propenes (5) are also formed.Mechanisms for these reactions are proposed.