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S-(4-chlorophenyl) 4-chlorobenzenesulfonothioate, also known as 4-chlorophenyl 4-chlorobenzenesulfonothioate, is an organic compound with the chemical formula C12H8Cl2O2S2. It is a colorless to pale yellow crystalline solid that is soluble in organic solvents. S-(4-chlorophenyl) 4-chlorobenzenesulfonothioate is primarily used as an intermediate in the synthesis of various agrochemicals, particularly herbicides and pesticides. It is characterized by its two chlorophenyl groups and a benzenesulfonothioate moiety, which contribute to its chemical reactivity and application in the production of crop protection products. Due to its potential environmental and health impacts, handling and disposal of this chemical should be done with proper safety measures and in accordance with local regulations.

1146-44-7

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1146-44-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1146-44-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,4 and 6 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1146-44:
(6*1)+(5*1)+(4*4)+(3*6)+(2*4)+(1*4)=57
57 % 10 = 7
So 1146-44-7 is a valid CAS Registry Number.

1146-44-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-chloro-4-(4-chlorophenyl)sulfonylsulfanylbenzene

1.2 Other means of identification

Product number -
Other names p-chlorophenyl-p-chlorobenzene-thiosulphonate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1146-44-7 SDS

1146-44-7Relevant academic research and scientific papers

Visible light induced decomposition of sulfonyl hydrazides using Pd/ZrO2nanocomposite photocatalyst

Li, Xiaoji,Zhou, Chao,Diao, Pinhui,Ge, Yanqin,Guo, Cheng

, p. 1296 - 1300 (2017)

A new approach to synthesis of thiosulfonates has been developed under mild conditions without any oxidants and promoting reagents through a Pd/ZrO2nanocomposite photocatalyst catalyzed decomposition of sulfonyl hydrazides. This protocol gave the products in moderate yields, comparable to the best results reported so far. Finally, a plausible reaction mechanism was proposed.

Copper-Catalyzed Aerobic Formation of Unstable Sulfinyl Radicals for the Synthesis of Sulfinates and Thiosulfonates

Shyam, Pranab K.,Kim, Yu Kwon,Lee, Chan,Jang, Hye-Young

, p. 56 - 61 (2016)

Copper-catalyzed aerobic coupling of thiols and alcohols affords sulfinates and thiosulfonates. These products are assumed to form via sulfinyl radicals which are not commonly found in oxidative coupling reactions of thiols. A reaction mechanism involving sulfinyl radicals is proposed, and mass and electron paramagnetic resonance (EPR) experimental results are provided.

Oxidation of disulfides with Selectfluor: Concise syntheses of thiosulfonates and sulfonyl fluorides

Kirihara, Masayuki,Naito, Sayuri,Ishizuka, Yuki,Hanai, Honoka,Noguchi, Takuya

, p. 3086 - 3089 (2011)

The reaction of aromatic or benzylic disulfides with 2.5 equiv of Selectfluor in acetonitrile/water (10:1) at room temperature efficiently produced the corresponding thiosulfonates. On the other hand, the reaction of disulfides with 6.5 equiv of Selectfluor in refluxing acetonitrile/water (10:1) provided sulfonyl fluoride in high yields.

Zinc dichromate trihydrate (ZnCrmiddot;3H) as an efficient reagent for the one-pot synthesis of thiosulfonates from thiols

Sobhani, Sara,Aryanejad, Sima,Maleki, Mahdi Faal

, p. 319 - 322 (2011)

ZnCrH is a readily available and efficient reagent for the one-pot synthesis of a variety of thiosulfonates by chemoselective oxidation of thiols. Georg Thieme Verlag Stuttgart New York.

TCCA-promoted solvent-free chemoselective synthesis of thiosulfonates on grinding

Xu, Yali,Peng, Yong,Sun, Junhui,Chen, Jiuxi,Ding, Jinchang,Wu, Huayue

, p. 358 - 360 (2010)

Trichloroisocyanuric acid (TCCA) is an inexpensive and efficient reagent for solvent-free chemoselective synthesis of thiosulfonates by grinding, providing a metal-free new methodology for the oxidation of disulfides. The important features of this method are that it is reasonably fast, very clean, high yielding, has a simple workup and is environmentally benign.

Synthesis of symmetrical / unsymmetrical thiosulfonates through the disproportionate coupling reaction of sulfonyl hydrazide mediated by phosphomolybdic acid

Lv, Mengting,Liu, Yufeng,Li, Ke,Yang, Guoping

supporting information, (2021/01/21)

Phosphomolybdic acid (H3PMo12O40) is reported as a green low-cost catalyst for the synthesis of symmetrical / unsymmetrical thiosulfonates via the disproportionate coupling reaction of sulfonyl hydrazide. The attributes of this reported catalytic system include low catalyst loadings (1 mol%), efficient turnover, and high yields (up to 94%). Additionally, this reaction mechanism involves the formation of a thiyl radical and sulfonyl radical via sulfinyl radical disproportionation.

Dual Roles of Rongalite: Reductive Coupling Reaction to Construct Thiosulfonates Using Sulfonyl Hydrazides

Zhang, Guofu,Fan, Qiankun,Zhao, Yiyong,Wang, Huimin,Ding, Chengrong

supporting information, p. 81 - 85 (2020/11/03)

A tunable and practical transformation of structurally diverse sulfonyl hydrazides into thiosulfonates in the presence of Rongalite (NaHSO 2·CH 2O) was developed. Transition-metal-free conditions, operational simplicity, and readily available reagents are the striking features of this protocol. It is the first example for the synthesis of thiosulfonates using sulfonyl hydrazides with the assistance of reductant. Additionally, the mechanistic studies revealed that this transformation probably undergoes via a reducing-coupling pathway.

Synthesis of Symmetrical Thiosulfonates via Cu(OTf)2-Catalyzed Reductive Homocoupling of Arenesulfonyl Chlorides

Liu, Lixia,Luo, Bo,Wang, Chengming

supporting information, p. 5880 - 5883 (2021/11/27)

A variety of symmetrical thiosulfonates are synthesized via Cu-catalyzed reductive homocoupling of aryl sulfonyl chlorides. This protocol uses organic amine acting as a mild reductant and low-cost copper as an effective catalyst. Such a reductive coupling process features a broad substrate scope and good functional group tolerance. Related thiosulfonate products can also be converted into diverse functional molecules.

The organocatalytic synthesis of perfluorophenylsulfides: Via the thiolation of trimethyl(perfluorophenyl)silanes and thiosulfonates

Cai, Zhihua,Du, Guangfen,He, Lin,Lin, Muze,Luo, Jinyun,Wu, Leifang

supporting information, p. 9237 - 9241 (2021/11/13)

The organic superbase t-Bu-P4-catalyzed direct thiolation of trimethyl(perfluorophenyl)silanes and thiosulfonates was developed. Yields of perfluorophenylsulfides of up to 97% under catalysis of 5 mol% t-Bu-P4 were achieved. This method was shown to provide an efficient way to construct the perfluorophenyl-sulfur bond under mild metal-free reaction conditions. This journal is

Metal-Free Radical Annulation of Oxygen-Containing 1,7-Enynes: Configuration-Selective Synthesis of (E)-3-((Arylsulfonyl)methyl)-4-Substituted Arylidenechromene Derivatives

Bian, Mouwang,Dai, Lei,Mao, Kaimin,Rong, Liangce,Wang, Chang,Yu, Qiuyu,Zhang, Jinghang

supporting information, p. 218 - 224 (2021/01/13)

A novel strategy for the synthesis of (E)-3-((arylsulfonyl)methyl)-4-substituted benzylidenechromene derivatives via a metal-free radical annulation reaction of oxygen-containing 1,7-enynes with thiosulfonates has been developed. The reaction shows broad substrate scope, wide functional group tolerance, and moderate to excellent yields. Moreover, thiosulfonates were well driven to achieve the bifunctionalization reaction of oxo-1,7-enynes which derived from aliphatic alkynes. In addition, the (E)-configuration of the products was highly controlled by the structure of 1,7-enyne.

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