
Synthesis p. 60 - 64 (1986)
Update date:2022-08-04
Topics:
Larcheveque, Marc
Petit, Yves
α-Hydroxyketones (OH-protected) are prepared in high enantiomeric purity by reaction of chiral O-protected 2-hydroxyalkanoic esters with organolithium compounds in ether/pentane at -100 deg C or by conversion of 2-hydroxyalkanoic esters into 2-hydroxy-N,N-dimethylalkanamides, O-protection of these amides, and reaction with organomagnesium bromides in tetrahydrofuran/ether at 5 deg C.
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(2003)Doi:10.1016/S0040-4039(00)92553-X
(1976)Doi:10.1007/BF00902822
(1951)Doi:10.1002/ejoc.201402551
(2014)Doi:10.1016/j.tet.2007.04.098
(2007)