61838-90-2

Usage

General Description

1H-Indole-2-carboxylic acid, 1,3-dimethyl-, ethyl ester is a chemical compound with the molecular formula C13H15NO2. It is an ethyl ester of 1H-indole-2-carboxylic acid with two methyl groups attached to the 1 and 3 positions of the indole ring. 1H-Indole-2-carboxylic acid, 1,3-dimethyl-, ethyl ester is commonly used as a building block in organic synthesis and pharmaceutical research. It may also have potential applications in the development of new drugs due to its structural properties and the presence of the indole ring, which is a common motif in many biologically active compounds. Additionally, it may be used as a flavoring agent in the food industry or as a fragrance in the cosmetic and perfume industry.

Upstream product

• 26304-51-8 ethyl 3-methyl-indole-2-carboxylate 
• 74-88-4 methyl iodide 
• 61838-82-2 Aethyl-2-(N-methylanilino)-acetoacetat 
• 100-61-8 N-methylaniline 
• 95239-03-5 tert-butyl 2-(4-ethoxy-4-oxobut-2-en-2-yl)diazene-1-carboxylate 
• 2142-69-0 2-bromophenyl methyl ketone 
• 167479-51-8 2-phenylhydrazono-butyric acid ethyl ester 
• 607-97-6 ethyl 2-ethyl-3-oxobutanoate 

Relevant academic research and scientific papers

Metal and Oxidant Free Construction of Substituted- and/or Polycyclic Indoles: A Useful Alternative to Bischler and Related Syntheses

A wide range of substituted indoles or polycyclic derivatives containing the indole core are easily accessible by acidic treatment of aromatic amines and 1,2-diaza-1,3-dienes. Unlike the related indole-Bischler synthesis, the regioselectivity of the method here reported is unique and predictable, the yields are generally good and also electron withdrawing substituted indoles are smoothly recovered.

5-MEMBERED HETEROCYCLE FUSED WITH [3,4-D]PYRIDAZINONE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF

The present invention provides a compound comprising a 5-membered heterocycle fused with a pyridazinone, wherein the compound is used as an FGFR kinase inhibitor, and a manufacturing method and application thereof. The invention specifically provides a co

Synthesis and biological activity of N-(aminoiminomethyl)-1H-indole carboxamide derivatives as Na+/H+ exchanger inhibitors

A series of N-(aminoiminomethyl)-1H-indole carboxamide derivatives were synthesized and their inhibitory potencies against the Na+/H+ exchanger were measured. Variation of the carbonylguanidine group at the 2- to 7- position of the indole ring system showed that a substitution at the 2- position improved the Na+/H+ exchanger inhibitory activity the most in vitro. This led to the synthesis and evaluation of an extensive series of N- (aminoiminomethyl)-1H-indole-2-carboxamide derivatives. Derivatives having an alkyl or substituted alkyl group at the 1-position of the indole ring system showed higher levels of in vitro activities. N-(aminoiminomethyl)-1-(2- phenylethyl)-1H-indole-2-carboxamide (49) had the strongest activity.