61871-82-7

Basic information

• Product Name: Ethanone, 1-(2-amino-5-bromophenyl)-2-chloro-
• CAS NO: 61871-82-7
• Molecular Formula: C8H7BrClNO
• Molecular Weight: 248.507
• Mol File: 61871-82-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(2-amino-5-bromophenyl)-2-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(2-amino-5-bromophenyl)-2-chloro-(61871-82-7)
• EPA Substance Registry System: Ethanone, 1-(2-amino-5-bromophenyl)-2-chloro-(61871-82-7)

Safety Data

• Hazardous Substances Data: 61871-82-7(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-(2-amino-5-bromophenyl)-2-chloro- is a chemical compound with the molecular formula C8H7BrClNO. It is a compound that contains a ketone group as well as amino, bromo, and chloro substituents on a phenyl ring. Ethanone, 1-(2-amino-5-bromophenyl)-2-chloro- is used in the field of organic chemistry as a building block for the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals. It may also have potential applications in medicinal chemistry as a precursor for the development of new drugs. Ethanone, 1-(2-amino-5-bromophenyl)-2-chloro-'s unique structure and properties make it a valuable tool for researchers in the development of novel compounds for various applications.

Upstream product

• 106-40-1 4-bromo-aniline 
• 107-14-2 chloroacetonitrile 

Downstream Products

• 10075-50-0 5-bromo-1H-indole 
• 683203-82-9 5-bromo-3-((4-fluorophenyl)thio)-1H-indole 
• 336186-58-4 5-bromo-3-((4-chlorophenyl)sulfanyl)-1H-indole 
• 1210054-38-8 5-bromo-3-((4-methoxyphenyl)sulfanyl)-1H-indole 
• 1210054-41-3 5-bromo-3-(phenylselanyl)-1H-indole 
• 164788-99-2 diethyl acetamido-(2-amino-5-bromophenacyl)-malonate 

Relevant articles and documents

Synergistic Cooperative Effect of Sodium borohydride-Iodine Towards Cascade C?N and C?S/Se Bond Formation: One-pot Regioselective Synthesis of 3-Sulfenyl/selenyl Indoles and Mechanistic Insight

In this work, a new strategy to synthesize 3-sulfenyl/selenyl indole is reported wherein LC?MS reveals a novel insight into synergistic cooperative effect of NaBH4-I2 which allows cascade C?N and C?S/C?Se bond formations via reduction-nucleophilic cyclization-chalcogenylation, three steps in one-pot, towards regioselective synthesis of diverse 3-chalcogenyl indoles including 5-bromo-3-[(3,4,5-trimethoxyphenyl)thio]-1H-indole, a known lead anticancer compound, directly from 2-amino-phenacylchlorides and thiophenols or disulfides/diselenides in aqueous dioxane under transition-metal-free condition. (Figure presented.).

Derivatives of kynurenine as inhibitors of rat brain kynurenine aminotransferase

The structural requirements of the catalytic site of kynurenine aminotransferase (KAT), the enzyme responsible for the conversion of L-kynurenine (KYN) to kynurenic acid (KYNA), were examined using analogs and derivatives of KYN. KYNA production from KYN was monitored in rat brain homogenates and brain tissue slices. Modification of KYN's acylalanine side chain or its ring amino group resulted in compounds which did not substantially affect KYNA synthesis. Ring chlorination in positions 3, 4, 5 and 6 yielded KYN analogs which interfered with KYNA production. L-5-Cl-KYN was the most active of the chlorinated kynurenines, and one of the most potent of several other 5-substituted kynurenines. L-5-Cl-KYN was an excellent substrate of KAT, yielding 6-Cl-KYNA. Finally, in kinetic studies, L-5-Cl-KYN (K(i) = 5.4 μM) was found to have an approximately five times higher affinity to the enzyme than the natural substrate KYN (K(m) = 28 μM).