61881-49-0

Basic information

• Product Name: Propanedioic acid, methyl(4-nitrophenyl)-, diethyl ester
• CAS NO: 61881-49-0
• Molecular Formula: C14H17NO6
• Molecular Weight: 295.292
• Mol File: 61881-49-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, methyl(4-nitrophenyl)-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, methyl(4-nitrophenyl)-, diethyl ester(61881-49-0)
• EPA Substance Registry System: Propanedioic acid, methyl(4-nitrophenyl)-, diethyl ester(61881-49-0)

Safety Data

• Hazardous Substances Data: 61881-49-0(Hazardous Substances Data)

Upstream product

• 350-46-9 4-Fluoronitrobenzene 
• 609-08-5 Diethyl methylmalonate 
• 100-00-5 4-chlorobenzonitrile 

Downstream Products

• 1332491-58-3 2-(4-iodophenyl)-2-methylpropane-1,3-diol 
• 1333468-71-5 2-(4-(4-methylpiperazin-1-yl)phenyl)propanamide 
• 1333468-70-4 2-(4-(4-methylpiperazin-1-yl)phenyl)propanoic acid 
• 1333468-69-1 diethyl 2-methyl-2-(4-(4-methylpiperazin-1-yl)phenyl)malonate 
• 1333468-68-0 diethyl 2-methyl-2-(4-(piperazin-1-yl)phenyl)malonate 
• 138569-22-9 Diethyl 2-methyl-2-<4-(4-trifluoromethyl)-4-hydroxy-2-thiazolin-2-yl)phenyl>malonate 
• 138569-18-3 Diethyl 2-<4-<4-(2,3-dibromopropyl)thiazol-2-yl>phenyl>-2-methylmalonate 
• 138569-21-8 Diethyl 2-<4-(4-carboxythiazol-2-yl)phenyl>-2-methylmalonate 
• 138569-12-7 Diethyl 2-<4-<4-(2-chloroethyl)thiazol-2-yl>phenyl>-2-methylmalonate 
• 139182-94-8 2-[4-(4-Methoxymethyl-thiazol-2-yl)-phenyl]-2-methyl-malonic acid diethyl ester 
• 138569-19-4 Diethyl 2-<4-(4-allylthiazol-2-yl)phenyl>-2-methylmalonate 
• 138569-20-7 Diethyl 2-<4-(4-chloromethylthiazol-2-yl)phenyl>-2-methylmalonate 

Relevant articles and documents

TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION

The present invention relates to compounds defined by formula I wherein the variables R1-R8 are defined as in the description, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of cholesterol ester transfer protein (CETP) and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme.

Nucleophilic aromatic substitution using Et3SiH/cat. t-Bu-P4 as a system for nucleophile activation

A novel type of deprotonative arylation of nucleophiles was conducted using Et3SiH/cat. t-Bu-P4 and the powerful SNAr reactions of aryl fluorides were accomplished using alcohols and malonates as nucleophiles. The Royal Society of Ch

Preparation and biological activity of 2-[4-(thiazol-2-yl)phenyl]propionic acid derivatives inhibiting cyclooxygenase

A series of 2-[4-(thiazol-2-yl)phenyl]propionic acids substituted at various positions were prepared by the reaction of diethyl 2-methyl-2-(4-thiocarbamoylphenyl)malonates with α-bromoaldehyde diethyl acetals or α-haloketones followed by hydrolysis of esters. The inhibition of prostaglandin H synthetase (cyclooxygenase) was assayed by use of an enzyme preparation from guinea pig polymorphonuclear leukocytes. Examination of the structure-activity relationship of these compounds indicated that the substitution pattern with halogens at position 3 (R1) of the benzene ring and a methyl group in position 4 (R2) and/or 5 (R3) of the thiazole ring were favorable for inhibitory activity. The compounds bearing bulky alkyl or polar functional groups at the R2 position were weak inhibitors. The potent inhibitors of cyclooxygenase were tested for their ability to reduce carrageenin-induced inflammation of rat paws. These derivatives had strong anti-inflammatory activity based on their strong inhibition of cyclooxygenase, with some exceptions, including those with a thiomethyl group at R1.