618892-18-5Relevant academic research and scientific papers
Synthesis of MMP inhibitor radiotracer [11C]CGS 25966, a new potential PET tumor imaging agent
Fei, Xiangshu,Zheng, Qi-Huang,Liu, Xuan,Wang, Ji-Quan,Stone, K. Lee,Miller, Kathy D.,Sledge, George W.,Hutchins, Gary D.
, p. 343 - 351 (2007/10/03)
[11C]CGS 25966, a novel radiolabeled matrix metalloproteinase (MMP) inhibitor, has been synthesized for evaluation as new potential positron emission tomography (PET) tumor imaging agent. The precursor was labeled by [11C]methyl triflate through O-[11C]methylation method at the hydroxyl position of phenol under basic conditions and isolated by HPLC purification to produce pure target compound in 15-25% radiochemical yield, based on 11CO2, decay corrected to end of bombardment. Copyright
