61926-37-2

Upstream product

• 33675-41-1 1-bromo-2-(4-methoxyphenyl)acetylene 
• 2227-57-8 3-(4-methoxyphenyl)propynoic acid 
• 768-60-5 4-methoxyphenylacetylen 
• 3989-14-8 (4-methoxyphenylethynyl)trimethylsilane 
• 123-11-5 4-methoxy-benzaldehyde 
• 1111758-19-0 1,1-diiodo-2-(4-methoxyphenyl)ethene 

Downstream Products

• 491593-73-8 1-(3,3-difluoro-2-iodo-cycloprop-1-enyl)-4-methoxy-benzene 
• 18277-20-8 hexadeca-7,9-diyne 
• 22779-05-1 1,4-bis(4-methoxyphenyl)-1,3-butadiyne 
• 151362-06-0 1,4-bis[4-(trifluoromethyl)phenyl]buta-1,3-diyne 
• 1016893-15-4 (E)-ethyl 2-ethanoyl-4-iodo-3-(4-methoxyphenyl)-2-methylbut-3-enoate 
• 24785-38-4 1-methoxy-4-[2-(4-methylphenyl)ethynyl]benzene 
• 1254083-95-8 2-phenyl-4-(4’-methoxyphenyl)-1,1-difluoro-1-butene-3-yne 
• 1335520-75-6 1-chloro-4-(1-(4-methoxyphenyl)-5-phenylpenta-1,4-diyn-3-yl)-benzene 
• 1335520-74-5 4,4'-(5-phenylpenta-1,4-diyne-1,3-diyl)bis(methoxybenzene) 
• 1390650-61-9 C₁₅H₁₃IN₄O 
• 130248-54-3 1-methoxy-4-[4-(trimethylsilyl)-1,3-butadiyn-1-yl]benzene 
• 2132-62-9 4,4'-dimethoxydiphenylacetylene 
• 2749-94-2 1-methoxy-4-(prop-1-yn-1-yl)benzene 

Relevant academic research and scientific papers

Synthesis method of 1-iodo-alkyne compound

The invention discloses a synthetic method of a 1-iodo-alkyne compound. The preparation method comprises the following steps: in an aerobic environment, mixing terminal alkyne, soluble inorganic iodized salt, sodium phenylsulfinate or a derivative thereof

Electrochemical Sulfonylation of Alkynes with Sulfonyl Hydrazides: A Metal- and Oxidant-Free Protocol for the Synthesis of Alkynyl Sulfones

Herein, an electrochemical oxidative cross-coupling reaction between terminal alkynes and sulfonylhydrazides has been developed. Tetrabutylammonium iodide is used as the electrolyte and redox medium. The significant advantages of this method are high atom efficiency, functional group tolerance, and transition metal- and oxidant-free conditions. Most of the compounds exhibit good inhibitory activity on tumor cell lines, and one of the compounds can inhibit cell migration and induce apoptosis in HeLa cells. (Figure presented.).

Au(I)-Catalyzed Hydration of 1-Iodoalkynes Leading to α-Iodoketones

A catalytic protocol for the Au(I)-catalyzed hydration of 1-iodoalkynes is disclosed. The use of Au(I)–NHC catalyst enabled the straightforward synthesis of a variety of α-iodomethyl ketones in good to excellent yields. The utility of this simple method is further highlighted by showcasing iodination/hydration and hydration/oxidation sequential protocols leading to the construction of molecular complexity.

Efficient synthesis of 1-iodoalkynes: Via Al2O3 mediated reaction of terminal alkynes and N -iodosuccinimide

Iodination of terminal alkynes using N-iodosuccinimide (NIS) in the presence of γ-Al2O3 was developed to afford 1-iodoalkynes with good to excellent yields (up to 99%). This described approach featured excellent chemoselectivity, good functional group tolerance, and utilization of an inexpensive catalyst.

Preparation method of 1-iodoalkyne

The invention discloses a preparation method of 1-iodoalkyne. The method comprises the following step: reacting a terminal alkyne compound with N-iodosuccinimide in a solvent in the presence of aluminum oxide and a molecular sieve to prepare a 1-iodoalkyn

Oxidative Addition of Alkenyl and Alkynyl Iodides to a AuI Complex

The first isolated examples of intermolecular oxidative addition of alkenyl and alkynyl iodides to AuI are reported. Using a 5,5′-difluoro-2,2′-bipyridyl ligated complex, oxidative addition of geometrically defined alkenyl iodides occurs readily, reversibly and stereospecifically to give alkenyl-AuIII complexes. Conversely, reversible alkynyl iodide oxidative addition generates bimetallic complexes containing both AuIII and AuI centers. Stoichiometric studies show that both new initiation modes can form the basis for the development of C?C bond forming cross-couplings.

Acetic Acid Promoted Direct Iodination of Terminal Alkynes with N -Iodosuccinimide: Efficient Preparation of 1-Iodoalkynes

An efficient and highly chemoselective approach for the direct iodination of terminal alkynes using acetic acid as N -iodosuccinimide activated reagent under metal-free conditions has been developed. This facile process tolerates a variety of terminal alkynes and provides the desired products in good to excellent yields (up to 99percent).

Design, synthesis and comparative analysis of triphenyl-1,2,3-triazoles as anti-proliferative agents

Herein, a series of triaryl-1,2,3-triazoles, in order to check cytotoxicity on breast cancer cell lines have been synthesized with pendent benzyl ring to mimic the phenolic A ring of Tamoxifene. The biological results indicated that most of the compounds

Synthesis of 5H-Selenopheno[3,2-c]isochromen-5-ones Promoted by Dialkyl Diselenides and Oxone

We describe here for the first time the synthesis of isochromenones fused to selenophenes. 5H-Selenopheno[3,2-c]isochromen-5-ones were obtained through a double intramolecular cyclization of methyl 2-(organyl-1,3-diynyl)benzoate promoted by electrophilic species of selenium generated in situ by the reaction of dialkyl diselenides with Oxone, using ethanol as solvent. The reactions were conducted satisfactorily under mild conditions, using a range of 1,3-diynes and dialkyl diselenides as substrates. A total of sixteen unprecedent 5H-selenopheno[3,2-c]isochromen-5-ones were selectively obtained in moderate to good yields (40–86%) under reflux in an open flask and in short reaction times (1.0–2.5 h). (Figure presented.).

Synthesis of fluoroalkylated alkynes: Via visible-light photocatalysis

Fluoroalkylated alkynes, which are versatile building blocks for the synthesis of various biologically active organofluorine compounds, were synthesized from easily available alkynyl halides and fluoroalkyl halides by visible-light photocatalysis. Addition of fluoroalkyl radicals to alkynes and subsequent dehalogenation selectively yielded fluoroalkylated alkynes.