61949-75-5

Basic information

• Product Name: 4-phenylpiperidin-2-one
• Synonyms: 4-phenylpiperidin-2-one;tetrahydro-4-phenyl-2H-Pyran-2-one
• CAS NO: 61949-75-5
• Molecular Formula: C₁₁H₁₂O₂
• Molecular Weight: 176.21
• Mol File: 61949-75-5.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 135 °C(Press: 0.4 Torr)
• Appearance: /
• Density: 1.150 g/cm3(Temp: 25 °C)
• CAS DataBase Reference: 4-phenylpiperidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-phenylpiperidin-2-one(61949-75-5)
• EPA Substance Registry System: 4-phenylpiperidin-2-one(61949-75-5)

Safety Data

• Hazardous Substances Data: 61949-75-5(Hazardous Substances Data)

Usage

General Description

4-phenylpiperidin-2-one, also known as piperidinone or desmolone, is a chemical compound with the molecular formula C11H13NO. It is a cyclic amide and a derivative of piperidine. The compound has a distinct piperidine ring structure with a phenyl group attached to the nitrogen atom. 4-phenylpiperidin-2-one has been studied and used in the synthesis of various pharmaceuticals and organic compounds. It has also been investigated for its potential pharmacological properties and has been found to exhibit some analgesic and anticonvulsant effects in animal studies. Additionally, 4-phenylpiperidin-2-one is used as an intermediate in the production of other chemical compounds and may have potential applications in medicinal chemistry and drug development.

Upstream product

• 4165-96-2 3-phenylglutaric acid 
• 761366-49-8 5-hydroxy-3-phenyl-valeric acid 
• 591-50-4 iodobenzene 
• 3393-45-1 5,6-dihydro-pyran-2-one 
• 7325-50-0 3-phenylpentanedial 
• 829-27-6 3-phenylpentane-1,5-diol 
• 3174-83-2 3-phenylbut-3-en-1-ol 
• 879-59-4 4-phenyl-5,6-dihydro-2H-pyran-2-one 
• 1392283-27-0 C₁₃H₁₄O₂ 
• 98-80-6 phenylboronic acid 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 591-51-5 phenyllithium 
• 52205-01-3 (5-methyl-2-phenyl-[1,3,2]dioxaborinan-5-yl)-methanol 
• 1352708-09-8 trimethyl((5-methyl-2-phenyl-1,3,2-dioxaborinan-5-yl)methoxy)silane 

Downstream Products

• 188670-33-9 7-Hydroxy-2-methyl-5-phenyl-heptanoic acid ethyl ester 
• 188670-37-3 7-Bromo-2-methyl-5-phenyl-heptanoic acid ethyl ester 
• 1123193-24-7 5-hydroxy-3-phenylpentanoic acid hydrazide 
• 138662-94-9 3(S)-azido-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-2-oxo-4(S)-phenyl-1-piperidineacetamide 
• 138571-14-9 3(S)-azido-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-2-oxo-4(R)-phenyl-1-piperidineacetamide 
• 138571-15-0 3(S)-amino-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-2-oxo-4(R)-phenyl-1-piperidineacetamide 
• 138662-95-0 3(S)-amino-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-2-oxo-4(S)-phenyl-1-piperidineacetamide 
• 138662-92-7 3-<4-(1,3-dioxolan-2-yl)-1-oxo-3(S)-phenyl-2(S)-azidobutyl>-4(S)-(phenylmethyl)-2-oxazolidinone 
• 138571-12-7 3-<4-(1,3-dioxolan-2-yl)-1-oxo-3(R)-phenyl-2(S)-azidobutyl>-4(S)-(phenylmethyl)-2-oxazolidinone 
• 138571-30-9 3-<4-(1,3-dioxolan-2-yl)-1-oxo-3(R)-phenylbutyl>-4(S)-(phenylmethyl)-2-oxazolidinone 
• 138571-11-6 3-<4-(1,3-dioxolan-2-yl)-1-oxo-3(S)-phenylbutyl>-4(S)-(phenylmethyl)-2-oxazolidinone 
• 138662-93-8 3-<2(S)-azido-1,5-dioxo-3(S)-phenylpentyl>-4(S)-phenylmethyl-2-oxazolidinone 
• 138571-13-8 3-<2(S)-azido-1,5-dioxo-3(R)-phenylpentyl>-4(S)-phenylmethyl-2-oxazolidinone 
• 138571-31-0 3(S)-azido-α(S)-butyl-2-oxo-4(S)-phenyl-1-piperidineacetic acid tert-butyl ester 

Relevant articles and documents

New Access Routes to Privileged and Chiral Ligands for Transition-Metal Catalyzed Hydrogen Autotransfer (Borrowing Hydrogen), Dehydrogenative Condensation, and Alkene Isomerization Reactions

A group of transition-metal catalyzed hydrogen moving reactions, encompassing hydrogen autotransfer (HAT; also called borrowing hydrogen, BH), dehydrogenative condensation (DHC) and alkene isomerization, displays high atom economy and relies on widely ava

Laccase/2,2,6,6-tetramethylpiperidinoxyl radical (TEMPO): An efficient catalytic system for selective oxidations of primary hydroxy and amino groups in aqueous and biphasic media

Copper salts/2,2,6,6-tetramethylpiperidinoxyl radical (TEMPO) catalytic systems enable efficient aerobic oxidations of primary alcohols but they generally show a reduced reactivity in aqueous medium. Herein, we report an oxidative catalytic system composed of Trametes versicolor laccase and TEMPO, which is able to work in buffer solutions at room temperature using ambient air. Although this catalytic system displays great efficiency in aqueous systems, the addition of methyl tert-butyl ether allows the reduction of TEMPO loading, also enhancing the solubility of hydrophobic compounds. This practical methodology promotes the chemoselective aerobic oxidation of hydroxy or amino groups, leading to interesting organic derivatives such as aldehydes, lactones, hemiaminals or lactams.

Dehydrogenative lactonization of diols in aqueous media catalyzed by a water-soluble iridium complex bearing a functional bipyridine ligand

A new catalytic system for the dehydrogenative lactonization of a variety of benzylic and aliphatic diols in aqueous media was developed. By using a water-soluble, dicationic iridium catalyst bearing 6,6′-dihydroxy-2, 2′-bipyridine as a functional ligand, highly atom economical and environmentally benign synthesis of various lactones was achieved in good to excellent yields. Recovery and reuse of the catalyst were also accomplished by a simple phase separation and the recovered catalyst maintained its high activity at least until the fifth run. Copyright