620-51-9

Basic information

• Product Name: Thiourea, N,N'-bis(3-methylphenyl)-
• CAS NO: 620-51-9
• Molecular Formula: C15H16N2S
• Molecular Weight: 256.371
• Mol File: 620-51-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Thiourea, N,N'-bis(3-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiourea, N,N'-bis(3-methylphenyl)-(620-51-9)
• EPA Substance Registry System: Thiourea, N,N'-bis(3-methylphenyl)-(620-51-9)

Safety Data

• Hazardous Substances Data: 620-51-9(Hazardous Substances Data)

Upstream product

• 108-44-1 1-amino-3-methylbenzene 
• 621-30-7 3-methylphenyl isothiocyanate 
• 137-26-8 Thiram 
• 97-74-5 bis(dimethylthiocarbamoyl)sulfide 
• 49791-44-8 ammonium salt of N-m-tolylamino dithiocarbamic acid 
• 75-15-0 carbon disulfide 
• 64-17-5 ethanol 
• 7722-84-1 dihydrogen peroxide 
• 56-23-5 tetrachloromethane 
• 463-71-8 thiophosgene 
• 17356-08-0 thiourea 

Downstream Products

• 726-28-3 N,N'-bis(m-methylphenyl)carbodiimide 
• 51131-78-3 N,N'-Bis(3-methylphenyl)guanidine 
• 620-22-4 3-Methylbenzonitrile 
• 621-30-7 3-methylphenyl isothiocyanate 
• 32826-84-9 3-(m-tolyl)thiazolidine-2,4-dione 
• 23233-41-2 3-m-tolyl-2-m-tolylimino-thiazolidin-4-one 
• 36220-32-3 (4-phenyl-3-m-tolyl-3H-thiazol-2-ylidene)-m-tolyl-amine 
• 79051-75-5 2-(m-tolylimino)-3-(m-tolyl)-4-(isobutyl)-Δ4-thiazoline 
• 82844-50-6 5,5-Bis-(2-hydroxy-phenyl)-2-thioxo-1,3-di-m-tolyl-imidazolidin-4-one 
• 82694-28-8 [4-Ethyl-5-methyl-3-m-tolyl-3H-thiazol-(2Z)-ylidene]-m-tolyl-amine 
• 79051-34-6 2-(m-tolylimino)-3-(m-tolyl)-4-(p-ethoxyphenyl)-Δ4-thiazoline 
• 82694-45-9 [4,5-Dimethyl-3-m-tolyl-3H-thiazol-(2Z)-ylidene]-m-tolyl-amine 
• 116690-09-6 5-methyl-2-phenyl-quinolin-4-ol 
• 69423-74-1 N,N'-di-m-tolyl thiovioluric acid 

Relevant articles and documents

Di-tert-butyl peroxide (DTBP)-mediated synthesis of symmetrical N,N′-disubstituted urea/thiourea motifs from isothiocyanates in water

ABATRACT: A direct approach to N,N′-disubstituted urea/thiourea from the self-condensation reactions of isothiocyanates in water has been developed. This access tolerated a wide range of functional groups on the aromatic ring, providing a practical and environment-friendly process to N,N′-disubstituted urea/thiourea in moderate to excellent yields from safe and easily available starting materials. A plausible mechanism of the desulfurization self-condensation reaction for urea was also proposed and the role of di-tert-butyl peroxide (DTBP) and copper catalyst in the present strategy was demonstrated with the help of ESI mass spectrometry of intermediate studies.

Synthesis of thioureas in ionic liquid medium

A highly efficient procedure for the synthesis of symmetrical thioureas by means of simple condensation of primary amines and carbon disulfide in 1-butyl-3-methylimidazolium chloride [BMIM][Cl] as a cheap and commercially available ionic liquid is presented. This procedure works for aromatic and aliphatic primary amines and give high to excellent yields of symmetrical thioureas without need for any catalyst or tedious work-up.

New potent imidazoisoquinolinone derivatives as anti-Trypanosoma cruzi agents: Biological evaluation and structure-activity relationships

A series of novel benzoimidazo and N-aryl-5-oxo-imidazo[1,2-b]isoquinoline-10-carbothioamides was developed. All the compounds were evaluated for their in vitro action against the epimastigote form of Trypanosoma cruzi. Four of them showed higher activity than Nifurtimox. Their unspecific cytotoxicity was evaluated using HeLa and L6 cells, being non-toxic at concentrations at least 15 and 200 times higher than that of T. cruzi IC50. To gain insight into the mechanism of action, their DNA binding properties and reactivity with glutathione were studied, and QSAR study was performed.