62006-53-5Relevant academic research and scientific papers
Potent and selective double-headed thiophene-2-carboximidamide inhibitors of neuronal nitric oxide synthase for the treatment of melanoma
Huang, He,Li, Huiying,Yang, Sun,Chreifi, Georges,Martásek, Pavel,Roman, Linda J.,Meyskens, Frank L.,Poulos, Thomas L.,Silverman, Richard B.
, p. 686 - 700 (2014/03/21)
Selective inhibitors of neuronal nitric oxide synthase (nNOS) are regarded as valuable and powerful agents with therapeutic potential for the treatment of chronic neurodegenerative pathologies and human melanoma. Here, we describe a novel hybrid strategy
Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors
-
, (2014/03/25)
Selective neuronal nitric oxide synthase (nNOS) inhibitor compounds designed with one or more thiophene-2-carboximidamide substituents for improved bioavailability.
Olefin cross-metathesis/Suzuki-Miyaura reactions on vinylphenylboronic acid pinacol esters
Baltus, Christine B.,Chuckowree, Irina S.,Press, Neil J.,Day, Iain J.,Coles, Simon J.,Tizzard, Graham J.,Spencer, John
, p. 1211 - 1217 (2013/03/13)
A series of alkenyl phenylboronic acid pinacol esters has been synthesized via an olefin cross-metathesis reaction of vinylphenylboronic acid pinacol ester derivatives. After catalytic hydrogenation, the resulting boronates were coupled via a microwave-mediated Suzuki-Miyaura reaction to afford a library of biarylethyl aryl and biarylethyl cycloalkyl derivatives. A complementary reaction sequence involved an initial Suzuki-Miyaura coupling.
Bidirectional photocontrol of peptide conformation with a bridged azobenzene derivative
Samanta, Subhas,Qin, Chuanguang,Lough, Alan J.,Woolley, G. Andrew
, p. 6452 - 6455 (2012/07/27)
It goes both ways: A thiol-reactive cross-linker based on a bridged azobenzene derivative permits photoreversible control of peptide conformation on irradiation with violet (407a nm) and green (500-550a nm) light (see picture) through isomerization of the
Reductive Coupling of Geminal Dichlorides by Iron(II) Oxalate Dihydrate
Khurana, Jitender M.,Maikap, Golak C.,Mehta, Sanjay
, p. 731 - 732 (2007/10/02)
A facile procedure for the quantitative conversion of geminal dichlorides to E olefins with iron(II) oxalate dihydrate in refluxing anhydrous dimethylformamide under a nitrogen atmosphere is described.The coupling proceeds via the corresponding vicinal dichlorides.
Electron Transfer in Competition with Loss of Nitrogen in Photochemical Reactions of Aryldiazomethane with Diethylamine
Tomioka, Hideo,Tabayashi, Kazuo,Izava, Yasuji
, p. 906 - 907 (2007/10/02)
The photolysis of aryldiazomethanes was studied as a function of aryl substituents and the p-nitro group was found to exert a special effect of product distribution.
Novel Bis as Antitrypanosomal Agents
Turner, William R.,Werbel, Leslie M.
, p. 1728 - 1740 (2007/10/02)
A series of novel 1,1'-(4,1-phenylene)bis was prepared and evaluated for activity against Trypanosoma rhodesiense in mice.The importance of the bis structure and the nature of the spacer between the two phenyl rings for optimal activity have been revealed.The potent parenteral activity of several analogues within this series as well as preliminary indication of oral activity lends encouragement to further development of this structural class.
