620628-24-2Relevant academic research and scientific papers
Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13)
Kim, Soong-Hoon,Pudzianowski, Andrew T.,Leavitt, Kenneth J.,Barbosa, Joseph,McDonnell, Patricia A.,Metzler, William J.,Rankin, Bruce M.,Liu, Richard,Vaccaro, Wayne,Pitts, William
, p. 1101 - 1106 (2007/10/03)
Computer aided drug design led to a new class of spiro-barbiturates (e.g., 4a, MMP-13 Ki = 4.7 nM) that are potent inhibitors of MMP-13.
SPIROBARBITURIC ACID DERIVATIVES USEFUL AS INHIBITORS OF MATRIX METALLOPROTEASES
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Page/Page column 48, (2010/02/07)
Compound having the formula (I),wherein A, B and D are O or S; R1a and R1b are H, C1-4 alkyl, C2-4alkenyl; X is-NR2-,-S-,-S(=O)-, or -S(O)2-; G1, G2 and G3
