5500-48-1

Upstream product

• 685-87-0 Diethyl 2-bromomalonate 
• 106-40-1 4-bromo-aniline 
• 5256-74-6 1,3-diethyl 2-diazopropanedioate 

Downstream Products

• 5683-27-2 N-(4-bromophenyl)-5,5-diethoxycarbonylpyrrolidone 
• 620627-99-8 1-(4-bromophenyl)-1,7,9-triazaspiro[4,5]decane-2,6,8,10-tetraone 
• 620628-24-2 N-(4-(phenyl)phenyl)-5,5-diethoxycarbonylpyrrolidone 
• 620628-34-4 C₁₆H₂₀BNO₇ 
• 848773-49-9 1-[4-(3-chloro-phenoxy)-phenyl]-5-oxo-pyrrolidine-2,2-dicarboxylic acid diethyl ester 
• 848773-48-8 1-[4-(4-chloro-phenoxy)-phenyl]-5-oxo-pyrrolidine-2,2-dicarboxylic acid diethyl ester 
• 848773-51-3 1-[4-(2-methoxy-phenoxy)-phenyl]-5-oxo-pyrrolidine-2,2-dicarboxylic acid diethyl ester 
• 848773-50-2 1-[4-(3-methoxy-phenoxy)-phenyl]-5-oxo-pyrrolidine-2,2-dicarboxylic acid diethyl ester 
• 848773-53-5 1-[4-(4-methoxy-pyridin-3-yloxy)-phenyl]-5-oxo-pyrrolidine-2,2-dicarboxylic acid diethyl ester 
• 848773-55-7 1-[4-(4-carboxy-phenoxy)-phenyl]-5-oxo-pyrrolidine-2,2-dicarboxylic acid diethyl ester 
• 848773-52-4 1-[4-(benzo[1,3]dioxol-5-yloxy)-phenyl]-5-oxo-pyrrolidine-2,2-dicarboxylic acid diethyl ester 
• 848773-54-6 1-[4-(4-methoxycarbonyl-phenoxy)-phenyl]-5-oxo-pyrrolidine-2,2-dicarboxylic acid diethyl ester 
• 848773-56-8 5-oxo-1-[4-(4-phenoxy-phenoxy)-phenyl]-pyrrolidine-2,2-dicarboxylic acid diethyl ester 
• 5683-24-9 5-oxo-1-phenyl-pyrrolidine-2,2-dicarboxylic acid diethyl ester 

Relevant academic research and scientific papers

Iridium catalyzed acceptor/acceptor carbene insertion into N-H bonds in water

The chemistry of A and D/A carbenes (D and A are donor and acceptor groups, respectively) is known to a great extent in the literature. Nevertheless the chemistry of the A/A class of carbenes is less explored, although the A/A class of carbenes is more im

Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13)

Computer aided drug design led to a new class of spiro-barbiturates (e.g., 4a, MMP-13 Ki = 4.7 nM) that are potent inhibitors of MMP-13.

SPIROBARBITURIC ACID DERIVATIVES USEFUL AS INHIBITORS OF MATRIX METALLOPROTEASES

Compound having the formula (I),wherein A, B and D are O or S; R1a and R1b are H, C1-4 alkyl, C2-4alkenyl; X is-NR2-,-S-,-S(=O)-, or -S(O)2-; G1, G2 and G3