62128-30-7

Basic information

• Product Name: (1-methyl-pyrrol-3-yl)(phenyl)methanone
• Synonyms: (1-methyl-pyrrol-3-yl)(phenyl)methanone;(1-Methyl-1H-pyrrol-3-yl)(phenyl)methanone;3-Benzoyl-1-methylpyrrole
• CAS NO: 62128-30-7
• Molecular Formula: C₁₂H₁₁NO
• Molecular Weight: 185.22184
• Mol File: 62128-30-7.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1-methyl-pyrrol-3-yl)(phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (1-methyl-pyrrol-3-yl)(phenyl)methanone(62128-30-7)
• EPA Substance Registry System: (1-methyl-pyrrol-3-yl)(phenyl)methanone(62128-30-7)

Safety Data

• Hazardous Substances Data: 62128-30-7(Hazardous Substances Data)

Usage

General Description

The chemical (1-methyl-pyrrol-3-yl)(phenyl)methanone, also known as 3'-methyl-1-(3-phenyl)propiophenone, is a compound with the molecular formula C14H13NO. It is a ketone derivative, containing a pyrrole ring with a methyl group and a phenyl ring. (1-methyl-pyrrol-3-yl)(phenyl)methanone is commonly used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also utilized in the production of various perfumes and flavors. Additionally, it has been studied for its potential pharmacological properties, including anti-inflammatory and neuroprotective effects. Overall, (1-methyl-pyrrol-3-yl)(phenyl)methanone has significant applications in the pharmaceutical and chemical industries due to its versatile properties and potential therapeutic benefits.

Upstream product

• 96-54-8 N-Methylpyrrole 
• 611-74-5 N,N-dimethylbenzamide 
• 98-88-4 benzoyl chloride 
• 120-94-5 1-Methylpyrrolidine 
• 611-73-4 Benzoylformic acid 
• 4229-44-1 N-methylhydroxyamine hydrochloride 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 58948-35-9 2-phenyl-1,3-benzoxathiolium tetrafluoroborate 
• 67-56-1 methanol 
• 139261-90-8 3-benzoyl-N-p-toluenesulfonylpyrrole 
• 112816-89-4 1-Methyl-3-(2-phenyl-benzo[1,3]oxathiol-2-yl)-1H-pyrrole 
• 37496-06-3 2-benzoyl-1-methyl-1H-pyrrole 

Downstream Products

• 157059-76-2 N-methyl-3-(phenylmethanol)pyrrole 

Relevant articles and documents

Regioselective Synthesis of Acylated N-Heterocycles via the Cascade Reactions of Saturated Cyclic Amines with 2-Oxo-2-arylacetic Acids

A highly regioselective and versatile synthesis of acylated N-heterocycles from the cascade reactions of saturated cyclic amines with 2-oxo-2-arylacetic acids is presented. Mechanistically, the formation of the title compounds involves first a C(sp3)-H bond dehydrogenation of cyclic amine to give an enamine intermediate followed by its cross coupling with the acyl species in situ generated through the decarboxylation of 2-oxo-2-arylacetic acid. Interestingly, in this cascade process, the copper catalyst is believed to play a crucial role not only in dehydrogenation but also in the decarboxylation and cross coupling reaction. To the best of our knowledge, this is the first example in which different classes of acylated N-heterocycles were directly prepared from the readily available saturated cyclic amines by using 2-oxo-2-arylacetic acids as the noncorrosive and easy to handle acylating reagents. Compared with literature methods, this new protocol has the advantages such as readily obtainable substrates, broad substrate scope, high efficiency, and good selectivity.

A mild and facile one-pot synthesis of N-methyl-3-acyl- pyrroles

N-Methyl-3-acylpyrroles were synthesized via a multicomponent reaction of dimethylacetylene dicarboxylate (DMAD), N-methylhydroxylamine and acylchlorides in the presence of KHCO3. For comparison both conventional and microwave protocols were examined in this procedure. The reaction is clean and gives the products in good to excellent yields under conventional heating conditions at 40 °C in anhydrous dichloromethane.