62134-48-9

Usage

Uses

Used in Pharmaceutical Research:
4-[(3-methylphenyl)amino]-4-oxobutanoic acid is used as a research compound for its potential anti-inflammatory and analgesic properties. It is being studied for its ability to modulate inflammatory responses and provide pain relief, making it a valuable asset in the development of new medications for various conditions.
Used in Organic Synthesis:
In the field of organic synthesis, 4-[(3-methylphenyl)amino]-4-oxobutanoic acid is used as a building block for the synthesis of more complex organic molecules. Its unique structure and functional groups make it a versatile component in the creation of novel compounds with potential applications in various industries.
Used in Neurological Disorder Treatment Research:
4-[(3-methylphenyl)amino]-4-oxobutanoic acid is being researched for its potential use in the treatment of various neurological disorders. Its chemical structure and properties suggest that it may have neuroprotective effects and could be utilized in the development of therapies for conditions such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis.
Used in Drug Development:
Due to its potential medical applications, 4-[(3-methylphenyl)amino]-4-oxobutanoic acid is used as a starting point for drug development. Its unique chemical properties and potential therapeutic effects make it an attractive candidate for further research and development in the pharmaceutical industry.

InChI:InChI=1/C11H13NO3/c1-8-3-2-4-9(7-8)12-10(13)5-6-11(14)15/h2-4,7H,5-6H2,1H3,(H,12,13)(H,14,15)

Upstream product

• 108-30-5 succinic acid anhydride 
• 108-44-1 1-amino-3-methylbenzene 

Downstream Products

• 93476-51-8 1-(m-tolyl)pyrrolidine-2,5-dione 
• 432492-51-8 1-(3-bromomethyl-phenyl)-pyrrolidine-2,5-dione 
• 3551-75-5 N,N'-bis(3-methylphenyl)oxalamide 

Relevant academic research and scientific papers

Synthesis of 3-(5-amino-1: H -1,2,4-triazol-3-yl)propanamides and their tautomerism

Two complementary pathways for the preparation of N-substituted 3-(5-amino-1H-1,2,4-triazol-3-yl)propanamides (5) were proposed and successfully realized in the synthesis of 20 representative examples. These methods use the same types of starting material

Ligand-based modelling followed by synthetic exploration unveil novel glycogen phosphorylase inhibitory leads

Glycogen phosphorylase (GP) is a valid anti-diabetic target. Accordingly, we applied a drug discovery workflow to unveil novel inhibitory GP leads via combining pharmacophore modeling, QSAR analysis and in silico screening, followed by synthetic exploration of active hits. Virtual screening identified six low micromolar inhibitory leads from the National Cancer Institute (NCI) list of compounds. The most potent hits exhibited anti-GP IC50 values of 3.2 and 4.1 μM. Synthetic exploration of hit 59 (IC50 = 4.1 μM) yielded 25 lead inhibitors with the best illustrating IC50 of 3.0 μM. Interestingly, we prepared several novel mixed oxalyl amide anti-GP leads employing new chemical reaction involving succinic acid-based adducts.

Solid-phase synthesis of N-aryl succinimides

A new method upon adopting a solid-phase strategy for synthesis of N-aryl succinimides is described here, using the silica-bound benzoyl chloride (SBBC) as dehydrating agent in reaction with N-arylsuccinamic acids. The main advantage of this method is the

Substituent chemical shifts of N-arylsuccinanilic acids, N-arylsuccinimides, N-arylmaleanilic acids, and N-arylmaleimides

NMR spectra of a series of N-arylsuccinanilic acids, N-arylsuccinimides, N-arylmaleanilic acids, and N-arylmaleimides were examined to estimate the electronic effect of the amide and imide groups on the chemical shifts of the hydrogen and carbon nuclei of the benzene ring.

A simple key for benzylic mono- and gem-dibromination of primary aromatic amine derivatives using molecular bromine1

Quantitative benzylic mono- and gem-dibromination on primary aromatic amine derivatives have been achieved using molecular bromine and by protecting the amino group as a succinimide moiety. The reactions of N-(o/m/p-tolyl)succinimides 5a-c with 1.25 equiv

Reactions of cyclic anhydrides with aromatic primary amines: Part 3 - Synthesis of novel 3-(N-arylcarbamoyl)- and 3-(N-naphthylcarbamoyl)carboxylic acids

Some hitherto unreported 3-(N-arylcarbamoyl)propenoic acids 7a-h and 3-(N-naphthylcarbamoyl)propenoic acid 9 have been synthesized in excellent yields, together with some propanoic acid analogues 11a-h and 12 as potential pesticides. Structural assignments of the products are based on elemental analyses and spectral (IR, 1H NMR, mass) data.