62172-57-0

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 82342-56-1 N-benzoyl-1,2,3,4-tetrahydroisoquinoline 
• 3230-65-7 3,4-dihydroisoquinoline 
• 151-50-8 potassium cyanide 
• 98-88-4 benzoyl chloride 
• 143-33-9 sodium cyanide 

Downstream Products

• 121451-89-6 2-Benzoyl-1-benzyl-1,2,3,4-tetrahydro-isoquinoline-1-carbonitrile 
• 121480-79-3 2-Benzoyl-1-(4-chloro-benzyl)-1,2,3,4-tetrahydro-isoquinoline-1-carbonitrile 
• 121451-90-9 2-Benzoyl-1-(2-chloro-benzyl)-1,2,3,4-tetrahydro-isoquinoline-1-carbonitrile 
• 75435-41-5 2-benzoyl-3,4-dihydroisoquinolin-1(2H)-one 
• 75435-38-0 1-hydroperoxy-2-benzoyl-1,2,3,4-tetrahydroisoquinaldonitrile 
• 627883-47-0 2-(2-benzoyl-1-cyano-1,2,3,4-tetrahydroisoquinoline-1-ylmethyl)benzoic acid ethyl ester 
• 1196-38-9 3,4-dihydroisoquinolin-1(2H)-one 
• 75435-39-1 Ethaneperoxoic acid 2-benzoyl-1-cyano-1,2,3,4-tetrahydro-isoquinolin-1-yl ester 
• 65-85-0 benzoic acid 
• 863643-81-6 1-(2-ethoxycarbonylbenzyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid 

Relevant academic research and scientific papers

Mild and highly efficient metal-free oxidative α-cyanation of N-acyl/sulfonyl tetrahydroisoquinolines

A highly efficient metal-free oxidative α-cyanation reaction of N-acyl/sulfonyl tetrahydroisoquinolines under mild conditions was developed. The reaction uses 2,2,6,6-tetramethylpiperidine N-oxide fluoroborate salt (T+BF4-

Protoberberines from Reissert- compounds. Part IX [1]. An alternative approach to dibenzoquinolizine- and isoquinonaphthyridin-13a-carboxylic acids, a novel synthesis of alangimarine

3,4-Dihydroisoquinoline-Reissert-compounds were alkylated to 1-benzyl- and 1-picolyl-derivatives, which in turn could selectively be hydrolized yielding various carboxylic acids, among others certain amino acids related to 3′,4′-deoxynorlaudanosoline carboxylic acid (DNLCA). These on treating with ethanolic KOH underwent cyclization to dibenzoquinolizine- and isoquinonaphthyridine-13a-carboxylic acids. Alternatively this cyclization also could be achieved by a more convenient one-pot procedure starting from the same dihydro-Reissert-compounds. Thermal decarboxylation afforded among others the alangia alkaloids alangimarine and dihydroalangimarine. Springer-Verlag 2004.

IMPROVED SYNTHESIS OF DIHYDROISOQUINOLINE REISSERT COMPOUNDS

Conversion of a series of 3,4-dihydroisoquinolines to their corresponding Reissert compounds was improved significantly over the usual reaction conditions by buffering the reaction medium at pH 8.

Organic Sonochemistry. Synthesis and Use of Reissert Compounds under PTC-Ultrasound

Use of phase transfer catalysis and ultrasound stirring improved the synthesis, alkylation and hydrolysis of several Reissert derivatives.