62218-63-7Relevant articles and documents
Use of lodoacetylene as a dipolarphile in the synthesis of 5-lodoisoxazole derivatives
Ku, Yi-Yin,Grieme, Tim,Sharma, Padam,Pu, Yu-Ming,Raje, Prasad,Morton, Howard,King, Steve
, p. 4185 - 4187 (2001)
(Equation Presented) Iodoacetylene 1 was prepared in situ from the reactions of ethynylmagnesium bromide or tributyl(ethynyl)tin with iodine. It was used as a dipolarphile in the [2 + 3] cyclization reaction with 1,3-dipolar nitrile oxide derivatives to p
A direct access to isoxazoles from ynones using trimethylsilyl azide as amino surrogate under metal/catalyst free conditions
Kumar, Gadi Ranjith,Kumar, Yalla Kiran,Reddy, Maddi Sridhar
supporting information, p. 6589 - 6592 (2016/06/01)
A general method for isoxazoles from readily available ynones using trimethylsilyl azide as an amino surrogate, likely via an unprecedented hydroazidation of the alkyne and denitrogenative cyclization, is demonstrated. The method neither required any cata
5-Substituted pyridylisoxazoles as effective inhibitors of platelet aggregation
Demina,Khodonov,Sinauridze,Shvets,Varfolomeev
, p. 2092 - 2113 (2015/06/08)
A series of 5-substituted 3-pyridylisoxazoles were synthesized using [3+2] cycloaddition of nitrile oxides to alkynes with variation of substituents at position 5 of the isoxazole ring without additional synthetic stages and with retention of 2-pyridyl-, 3-pyridyl, and 4-pyridyl substituents at position 3 of the isoxazole ring. Substituted pyridylisoxazoles are the potential antiaggregatory agents showing in vitro activity in the concentration range from 1?10-6 mol L-1 to 1?10-4 mol L-1 toward the human platelet rich blood plasma with arachidonic acid being used as the inductor of aggregation. These compounds do not act as cyclooxygenase or thromboxane synthase inhibitors, nor as thrombin inhibitors.
