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N-(4,5-dihydroacenaphtho[5,4-d][1,3]thiazol-8-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxamide is a complex organic compound with a molecular formula of C21H17N3OS. It is characterized by a naphthalene-2-carboxamide core, which is fused with a tetrahydro structure, and further adorned with a 4,5-dihydroacenaphtho[5,4-d][1,3]thiazol-8-yl group. N-(4,5-dihydroacenaphtho[5,4-d][1,3]thiazol-8-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxamide is known for its potential applications in the pharmaceutical industry, particularly as a chemical intermediate in the synthesis of drugs targeting various therapeutic areas. Its structure provides a unique combination of aromatic and heterocyclic systems, which can contribute to specific biological activities. The compound's synthesis and properties are of interest to researchers in medicinal chemistry due to its potential to influence pharmacokinetic and pharmacodynamic properties of drugs.

6224-95-9

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6224-95-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 6224-95-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,2,2 and 4 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 6224-95:
(6*6)+(5*2)+(4*2)+(3*4)+(2*9)+(1*5)=89
89 % 10 = 9
So 6224-95-9 is a valid CAS Registry Number.

6224-95-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name diphenyl(1-propynyl)phosphine oxide

1.2 Other means of identification

Product number -
Other names Diphenyl-prop-1-inyl-phosphinoxid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6224-95-9 SDS

6224-95-9Relevant academic research and scientific papers

The Diels-Alder reaction of diphenyl(1,2-propadienyl)phosphine oxide and diphenyl(1-propynyl)phosphine oxide with cyclopentadiene

Maffei, Michel

, p. 1323 - 1328 (2004)

The Diels-Alder reaction of diphenyl(1,2-propadienyl)phosphine oxide 1 and diphenyl(1-propynyl)phosphine oxide 2 with cyclopentadiene is reported. 1 reacts smoothly at room temperature in the presence of one equivalent of aluminum trichloride to give the corresponding adducts endo 3a and exo 3b (90:10 ratio) whose structure was attributed on the basis of their 13C NMR spectra, whereas 2 is a poor dienophile, affording the corresponding adduct in low yield even under harsh conditions.

Synthesis of diarylenynes by olefination of 1-arylpropyne with arylaldehyde and their optical properties

Shinohara, Kenta,Nishida, Takanori,Wada, Ryosuke,Peng, Lifen,Minoda, Yuju,Orita, Akihiro,Otera, Junzo

, p. 4427 - 4434 (2016/07/06)

A new synthetic protocol of 1-arylpropyne was developed by taking advantage of 1-(diphenylphosphoryl)propyne as propyne equivalent in Sonogashira coupling: consecutive subjection of phosphorylpropyne to t-BuOK and to aryl halides in the presence of Pd and Cu catalysts afforded the corresponding 1-arylpropynes. The following olefination of the 1-arylpropyne with aldehyde provided the corresponding diarylenyne. When the enynes thus obtained were irradiated with UV light, they showed strong emission in organic solvents and in the solid states. In solution, Ph2N-substituted enynes exhibited remarkable solvatofluorochromism, and Lippert–Mataga plot analysis demonstrated that they undergo the larger polarization in the excited states than in the ground states.

Stereoselective inverse conjugate addition of nitrogen and carbon nucleophiles to allenyl phosphine oxide. Synthesis of α,β-unsaturated phosphine oxides

De Los Santos, Jesus M.,Ochoa, Zelai,Palacios, Francisco

experimental part, p. 54 - 62 (2012/03/10)

The reactivity of new three carbon synthon, generated in situ from the reaction of electrondeficient allenes with an appropriate phosphine as the catalyst, toward pronucleophilic reagents is described. Triphenylphosphine- catalyzed reaction of allenes derived from phosphine oxides with nitrogen- or carbonucleophiles gave the γ-addition product as a mixture of cis and trans isomers. ARKAT-USA, Inc.

Zn(OTf)2 catalyzed addition-cyclization reaction of allenylphosphine oxides with propargyl alcohol-unexpected formation of 2,5-dimethylenetetrahydrofurans and 2-substituted furans

Srinivas, Venu,Sajna,Kumara Swamy

body text, p. 5323 - 5326 (2011/10/19)

A novel synthesis of 2,5-dimethylenetetrahydrofurans, 2-substituted furans and a β,ω-diketophosphonate in good to excellent yields has been achieved by the reaction of allenylphosphine oxides/allenylphosphonate with propargyl alcohol using zinc triflate/t

Efficient palladium-catalyzed double arylation of phosphonoalkynes and diarylalkynes in water: Use of a dinuclear palladium(I) catalyst

Sajna,Srinivas, Venu,Kumara Swamy

scheme or table, p. 3069 - 3081 (2011/02/22)

A novel use of the dinuclear palladium(I) catalyst [(OCH 2CMe2CH2O)P-S-Pd(PPh3)]2 in aqueous medium for the double arylation of phosphonoalkynes as well as diarylalkynes is reported. This double arylation requires both the iodoarene and arylboronic acid along with the catalyst. The structures of some key products have been proven by X-ray crystallography. Copyright

Phosphine-catalyzed synthesis of unsymmetrical 1,3-bis- and trisphosphorus ligands

Lin, Yi,Bernardi, Dan,Doris, Eric,Taran, Frédéric

experimental part, p. 1466 - 1470 (2011/04/15)

Phosphine-catalyzed umpolung γ-additions of phosphorus pronucleophiles on alkynes bearing phosphinoyl (P=O) or phosphinothioyl (P=S) moieties have been explored. The reaction leads to bis- or trisphosphorus subunits that can be useful for the preparation of chelating ligands. Georg Thieme Verlag Stuttgart.

Quaternary ammonium salts as alkylating agents in the synthesis of tertiary phosphine oxides

Zalinyan, S. A.,Khachatryan, R. A.,Indzhikyan, M. H.

, p. 388 - 390 (2007/10/03)

A procedure was developed for the synthesis of tertiary phosphine oxides by alkylation of secondary phosphine oxides with quaternary ammonium salts.

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