6225-06-5

Usage

Uses

Used in Pharmaceutical Industry:
N,N-Dimethylvaleramide is used as a solvent and a precursor in the production of various pharmaceuticals. It aids in the synthesis and formulation of drugs, enhancing their solubility and bioavailability.
Used in Agrochemical Industry:
N,N-Dimethylvaleramide serves as a precursor in the production of agrochemicals, contributing to the development of effective pesticides and other agricultural chemicals.
Used in Organic Synthesis:
N,N-Dimethylvaleramide is utilized as a reagent in organic synthesis, facilitating various chemical reactions and the formation of desired products.
Used in Fragrance and Flavor Industry:
N,N-Dimethylvaleramide is employed as an intermediate in the production of fragrances and flavors, contributing to the creation of diverse scents and tastes in various consumer products.
Precaution:
While N,N-Dimethylvaleramide is considered low in toxicity, it should be handled with care to avoid potential irritation to the skin, eyes, and respiratory system due to prolonged or repeated exposure.

InChI:InChI=1/C7H15NO/c1-4-5-6-7(9)8(2)3/h4-6H2,1-3H3

Upstream product

• 124-40-3 dimethyl amine 
• 109-52-4 valeric acid 
• 638-29-9 n-valeryl chloride 
• 109-72-8 n-butyllithium 
• 68-12-2 N,N-dimethyl-formamide 
• 2680-03-7 N,N-Dimethylacrylamide 
• 592-41-6 1-hexene 
• 4137-10-4 DIMCARB 
• 56379-68-1 S-phenyl thio-n-valerate 
• 693-04-9 butyl magnesium bromide 
• 1191-47-5 dibutylmagnesium 
• 127-19-5 N,N-dimethyl acetamide 
• 106-94-5 propyl bromide 

Downstream Products

• 89789-80-0 (4-Benzyloxycarbonylamino-nonyl)-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Palladium-Catalyzed Aminocarbonylation of Aliphatic Alkenes with N,N-Dimethylformamide as an in Situ Source of CO

The palladium-catalyzed aminocarbonylation of aliphatic alkenes is presented for the first time without the need for external CO pressure. N,N-dimethylformamide (DMF) is used as an in situ source of both the required carbon monoxide and the amine substrate. The applied palladium catalytic system is well-known for a number of carbonylation reactions, including those with CO surrogates and tandem isomerizing carbonylations. The reaction pathway was investigated and proved to proceed by an acid-catalyzed DMF decomposition to CO and dimethyl amine with subsequent aminocarbonylation of the alkene. Pressure-versus-time curves gave more insight into the correlation between acid concentration and aminocarbonylation activity. Aliphatic alkenes (terminal and internal) are transformed, also in commercial glassware, into the corresponding linear N,N-dimethylamides with excellent selectivities. Hence, amide synthesis by aminocarbonylation moves closer to application in standard organic laboratories. Do-it-yourself CO production: The aminocarbonylation of alkenes for aliphatic amide synthesis is presented for the first time using N,N-dimethylamine as an in situ source of both, the required CO and dimethylamine. Excellent selectivities to the linear product are ensured by isomerizing carbonylation applying a [Pd]/1,2-DTBPMB system. 1,2-DTBPMB=1,2-bis((di-tert-butylphos- phino)methyl)benzene.

Direct catalytic formation of primary and tertiary amides from non-activated carboxylic acids, employing carbamates as amine source

The operationally simple titanium(IV)- or zirconium(IV)-catalyzed direct amidation of non-activated carboxylic acids with ammonium carbamates generates primary, and tertiary N,N-dimethyl-substituted amides in good to excellent yields. Copyright

Product selectivity in the electroreduction of thioesters

The electroreduction of differently substituted aromatic and aliphatic thioesters (RCOSR′) led to regioselective reactions depending on the nature of the substituents. Thus, the cleavage between the carbonyl group and the SR′ group afforded α-diketones an

Vinyl-λ3-iodanes act as efficient sulfur atom acceptors: Vinylic SN2-based strategy for conversion of tertiary thioamides to amides

Exposure of tertiary thioamides to (E)-1-hexenyl(phenyl)-λ3-iodane results in vinylic SN2 reaction to give the inverted (Z)-S-vinylthioimidonium salts, which under alkaline hydrolysis (Na2CO3 or K2CO

Tetramethylammonium phenyltrialkylborates in the photoinduced electron transfer reaction with benzophenone. Generation of alkyl radicals and their addition to activated alkenes

Photoinduced one electron oxidation of tetramethylammonium phenyltrialkylborates by the excited state of benzophenone in an acetonitrile/benzene solution containing an excess of activated alkene produces substantially more than one equivalent of the alkyl radicals. The corresponding adducts of alkyl radicals to the alkenes are produced in good yields. No phenyl radical adducts are observed.

Synthesis of amides

Alkyl amides have been synthesized from cyclic anhydrides, carboxyl acids and their esters by contacting them with an amine carbamic acid salt.